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Phenoxybenzamine is more potent in inactivating alpha 1- than alpha 2-adrenergic receptor binding sites

European Journal of Pharmacology

Oct 14, 1983

K P Minneman

Abstract

The effects of phenoxybenzamine on alpha 1- and alpha 2-adrenergic receptor binding sites were examined directly using radioligand binding assays of the antagonist drugs [125I]BE 2254 and [3H]rauwolscine, respectively, in homogenates of rat cerebral cortex. Treatment with phenoxybenzami...read more

Mentioned in this Paper

Yohimbin Spiegel
Phenoxybenzamine Hydrochloride
August Rats
Rauwolscine
Adrenergic Receptor
BE 2254, (+-)-isomer
Tetralones
Insula of Reil
Cerebral Cortex
Phenoxybenzamine
Paper Details
References
  • References5
  • Citations13
12

Phenoxybenzamine is more potent in inactivating alpha 1- than alpha 2-adrenergic receptor binding sites

European Journal of Pharmacology

Oct 14, 1983

K P Minneman

PMID: 6317400

DOI: 10.1016/0014-2999(83)90458-2

Abstract

The effects of phenoxybenzamine on alpha 1- and alpha 2-adrenergic receptor binding sites were examined directly using radioligand binding assays of the antagonist drugs [125I]BE 2254 and [3H]rauwolscine, respectively, in homogenates of rat cerebral cortex. Treatment with phenoxybenzami...read more

Mentioned in this Paper

Yohimbin Spiegel
Phenoxybenzamine Hydrochloride
August Rats
Rauwolscine
Adrenergic Receptor
BE 2254, (+-)-isomer
Tetralones
Insula of Reil
Cerebral Cortex
Phenoxybenzamine

Related Papers

Paper Details
References
  • References5
  • Citations13
12
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