Phenprocoumon-induced liver disease ranges from mild acute hepatitis to (sub-) acute liver failure

Journal of Hepatology
Carl C SchimanskiAnsgar W Lohse

Abstract

Except for bleeding complications, other serious adverse reactions of coumarin anticoagulants such as hepatotoxicity or skin necrosis are comparatively rare. Nonetheless, a small number of coumarin-induced (sub-) acute liver failures has been published. A retrospective analysis was performed of patients treated for liver disease between 1992 and 2002 at our department to evaluate the incidence, clinical findings and histopathology of coumarin-induced hepatotoxicity. The retrospective analysis revealed eight cases of phenprocoumon-induced hepatotoxicity, including three cases of (sub-) acute liver failure which resulted in two orthotopic liver transplantations and one fatal outcome. Five patients with phenprocoumon-induced hepatitis recovered well after anticoagulation was switched to another coumarin derivate or subcutaneous low molecular weight heparin. In all patients liver injury was predominantly of an hepatitic type. In the cases of (sub-) acute liver failure massive confluent liver cell necroses were histologically present, whereas among patients without liver failure mild portal to moderate active lobular hepatitis were observed. A retrospective analysis by BfArM (German Federal Institute for Drugs and Medical Devices) r...Continue Reading

References

Jun 27, 1991·The New England Journal of Medicine·J Hirsh
Nov 1, 1990·Journal of Hepatology·R A de ManE van Leer
Jan 1, 1988·European Journal of Clinical Pharmacology·J X de VriesE Weber
Aug 1, 1980·Archives of Internal Medicine·G Slagboom, E A Loeliger
Oct 26, 1995·The New England Journal of Medicine·W M Lee
Nov 3, 1995·Deutsche medizinische Wochenschrift·S WoolleyU Zellweger
May 18, 1999·Seminars in Thrombosis and Hemostasis·S EhrenforthI Scharrer
Nov 5, 1999·Digestion·H MixM P Manns
Jan 6, 2001·Herz·M JeserichC Heilmann
May 22, 2001·Deutsche medizinische Wochenschrift·A R SchneiderJ F Riemann
Nov 29, 2001·The Annals of Pharmacotherapy·M A González de la PuenteJ M Varela
May 2, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B G LakeR J Price
Jun 8, 2002·Pharmacoepidemiology and Drug Safety·R ZaidensteinA Golik
Jun 5, 2003·International Journal of Clinical Pharmacology and Therapeutics·H J Schmeck-LindenauJ Schnitker
Aug 2, 2003·The New England Journal of Medicine·William M Lee
Aug 9, 2003·Expert Opinion on Drug Safety·I JörgJ Harenberg
Sep 13, 2003·Deutsche medizinische Wochenschrift·A CordesK P Maier

❮ Previous
Next ❯

Citations

Apr 9, 2005·Current Opinion in Gastroenterology·Susan K LazerowJames H Lewis
Nov 29, 2011·Der Internist·C PennartzJ J Meier
Sep 28, 2014·Expert Opinion on Drug Metabolism & Toxicology·Christoph G Dietrich, Andreas Geier
Mar 1, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Johannes HademUNKNOWN Acute Liver Failure Study Group Germany
Dec 3, 2014·British Journal of Clinical Pharmacology·Antonios DourosEdeltraut Garbe
Mar 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Johannes HademAndrea S Schneider
Jun 14, 2017·Wiener medizinische Wochenschrift·Christoph Sucker, Jens Litmathe
Apr 19, 2006·Circulation·Nipun Arora, Samuel Z Goldhaber
Aug 20, 2020·Der Pathologe·K ApelU Drebber
Nov 25, 2011·Deutsches Ärzteblatt International·Ali CanbayMichael P Manns
Jun 22, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Martin Reike-KunzeMarcial Sebode

❮ Previous
Next ❯

Related Concepts

Related Feeds

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Allen D BrinkerLeonard B Seeff
American Journal of Respiratory and Critical Care Medicine
Jussi J SaukkonenATS (American Thoracic Society) Hepatotoxicity of Antituberculosis Therapy Subcommittee
Journal of Clinical Gastroenterology
Vamsee AllaHerbert L Bonkovsky
Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
Hanan A Bin-NakhiYousef Habeeb
© 2022 Meta ULC. All rights reserved