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Phenylalkyl isoselenocyanates vs phenylalkyl isothiocyanates: thiol reactivity and its implications

Chemico-biological Interactions

Sep 18, 2012

Melissa A CrampsieArun K Sharma

Abstract

Phenylalkyl isoselenocyanate (ISC) compounds were recently designed in our laboratory by incorporating the anticancer element selenium into a panel of phenylalkyl isothiocyanates (ITCs), known to have anticancer properties. A structural activity investigation was carried out to compare ...read more

Mentioned in this Paper

DTNB gene
NFS1 gene
Glutathione Measurement
Mammary Neoplasms
Isothiocyanates
Selenium Compounds, Inorganic
Metabolic Inhibition
Assay
Negative Regulation of Cell Cycle
Negative Regulation of G2 to M Transition
Paper Details
References
  • References26
  • Citations7
123

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Phenylalkyl isoselenocyanates vs phenylalkyl isothiocyanates: thiol reactivity and its implications

Chemico-biological Interactions

Sep 18, 2012

Melissa A CrampsieArun K Sharma

PMID: 22982772

DOI: 10.1016/j.cbi.2012.08.022

Abstract

Phenylalkyl isoselenocyanate (ISC) compounds were recently designed in our laboratory by incorporating the anticancer element selenium into a panel of phenylalkyl isothiocyanates (ITCs), known to have anticancer properties. A structural activity investigation was carried out to compare ...read more

Mentioned in this Paper

DTNB gene
NFS1 gene
Glutathione Measurement
Mammary Neoplasms
Isothiocyanates
Selenium Compounds, Inorganic
Metabolic Inhibition
Assay
Negative Regulation of Cell Cycle
Negative Regulation of G2 to M Transition

Similar Papers Found In These Feeds

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Paper Details
References
  • References26
  • Citations7
123
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