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Phenylbutazone-warfarin interaction in the dog
The Journal of Pharmacy and Pharmacology
Nov 1, 1975
Kenneth A. Bachmann, A M Burkman
PMID: 1491
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Abstract
The administration of phenylbutazone together with warfarin to dogs resulted in an elevation of the free fraction of warfarin in the plasma from 2-6 to 8-0% thus providing direct support for the notion that phenylbutazone induced inhibition of warfarin binding to plasma proteins. This i...read more
Mentioned in this Paper
Oral Cavity
Body Surface Area Formula for Dogs
Factor II Deficiency
Canis familiaris
Dog family
Inherited Factor II Deficiency
Metabolic Inhibition
Gen-Warfarin
Prothrombin
Half-Life
Paper Details
References
- References6
- Citations3
Observations on the antirheumatic and physiologic effects of phenylbutazone (butazolidin) and some comparisons with cortisone
The American Journal of MedicineFebruary 1, 1954Bridget BrodieJennifer M Steele
Liquid chromatographic assay of warfarin: similarity of warfarin half-lives in human subjects
ScienceApril 26, 1974Elliot S Vesell, Carol A Shively
Warfarin. Stereochemical aspects of its metabolism and the interaction with phenylbutazone
The Journal of Clinical InvestigationJune 1, 1974R Jeffrey LewisW L Schary
Jugular puncture in the dog
The Veterinary RecordSeptember 21, 1968G J R Hovell
Pharmacokinetic analysis of potentiating effect of phenylbutazone on anticoagulant action of warfarin in man
Journal of Pharmaceutical SciencesSeptember 1, 1970Rebecca O'Reilly, Gary A LevyPhenylbutazone-sodium warfarin binding using a fluorescent probe technique
Journal of Pharmaceutical SciencesNovember 1, 1972H W JunP L Hsu
18
1
- References6
- Citations3
Cytochrome P450-mediated warfarin metabolic ability is not a critical determinant of warfarin sensitivity in avian species: In vitro assays in several birds and in vivo assays in chicken
Environmental Toxicology and ChemistryMay 12, 2015Kensuke P WatanabeMayumi IshizukaPharmaceutical sciences--1975: literature review of pharmaceutics II
Journal of Pharmaceutical SciencesAugust 1, 1976F W Goodhart, M L Eichman
Influence of 3,4-benzo(a)pyrene on warfarin hypoprothrombinemia and disposition in the rat
Toxicology and Applied PharmacologyOctober 1, 1977Kenneth A. Bachmann, Joan B Tarloff
3
19
1
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Phenylbutazone-warfarin interaction in the dog
Abstract
The administration of phenylbutazone together with warfarin to dogs resulted in an elevation of the free fraction of warfarin in the plasma from 2-6 to 8-0% thus providing direct support for the notion that phenylbutazone induced inhibition of warfarin binding to plasma proteins. This i...read more
Mentioned in this Paper
Oral Cavity
Body Surface Area Formula for Dogs
Factor II Deficiency
Canis familiaris
Dog family
Related Papers
Paper Details
References
- References6
- Citations3
Observations on the antirheumatic and physiologic effects of phenylbutazone (butazolidin) and some comparisons with cortisone
The American Journal of MedicineFebruary 1, 1954Bridget BrodieJennifer M SteeleLiquid chromatographic assay of warfarin: similarity of warfarin half-lives in human subjects
ScienceApril 26, 1974Elliot S Vesell, Carol A ShivelyWarfarin. Stereochemical aspects of its metabolism and the interaction with phenylbutazone
The Journal of Clinical InvestigationJune 1, 1974R Jeffrey LewisW L ScharyJugular puncture in the dog
The Veterinary RecordSeptember 21, 1968G J R HovellPharmacokinetic analysis of potentiating effect of phenylbutazone on anticoagulant action of warfarin in man
Journal of Pharmaceutical SciencesSeptember 1, 1970Rebecca O'Reilly, Gary A LevyPhenylbutazone-sodium warfarin binding using a fluorescent probe technique
Journal of Pharmaceutical SciencesNovember 1, 1972H W JunP L Hsu
18
1
- References6
- Citations3
Cytochrome P450-mediated warfarin metabolic ability is not a critical determinant of warfarin sensitivity in avian species: In vitro assays in several birds and in vivo assays in chicken
Environmental Toxicology and ChemistryMay 12, 2015Kensuke P WatanabeMayumi IshizukaPharmaceutical sciences--1975: literature review of pharmaceutics II
Journal of Pharmaceutical SciencesAugust 1, 1976F W Goodhart, M L EichmanInfluence of 3,4-benzo(a)pyrene on warfarin hypoprothrombinemia and disposition in the rat
Toxicology and Applied PharmacologyOctober 1, 1977Kenneth A. Bachmann, Joan B Tarloff
3
19
1
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