Nov 1, 1975

Phenylbutazone-warfarin interaction in the dog

The Journal of Pharmacy and Pharmacology
K Bachmann, A M Burkman


The administration of phenylbutazone together with warfarin to dogs resulted in an elevation of the free fraction of warfarin in the plasma from 2-6 to 8-0% thus providing direct support for the notion that phenylbutazone induced inhibition of warfarin binding to plasma proteins. This inhibition as evaluated by a kinetic method was accompanied by a two-fold decrease in the plasma half-life of warfarin from 18-4 h in control animals to 9-6 h in phenylbutazone-treated animals. Marked increases in warfarin-induced hypoprothrombinaemia were observed when at doses up to 8 mg kg-1 (orally) it was given with phenylbutazone (50 mg kg-1, orally). The unbound fraction of warfarin in canine plasma ranged from 1-7 to 4-3% indicating individual differences in the extent of the plasma binding of warfarin in the dog.

Mentioned in this Paper

Inherited Factor II Deficiency
Plasma Protein Binding Capacity
Plasma Proteins
Body Surface Area Formula for Dogs
Drug Interactions
Metabolic Inhibition
Factor II Deficiency

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