Phenylbutenoid dimers isolated from Zingiber purpureum exert neurotrophic effects on cultured neurons and enhance hippocampal neurogenesis in olfactory bulbectomized mice

Neuroscience Letters
Nobuaki MatsuiMasaaki Akagi

Abstract

Trans-3-(3'4'-dimethoxyphenyl)-4-[(E)-3",4"-dimethoxystyryl]cyclohex-1-ene (Comp.1) and cis-3-(3'4'-dimethoxyphenyl)-4-[(E)-3",4"-dimethoxystyryl]cyclohex-1-ene (Comp.2), phenylbutenoid dimers, have been isolated as neurotrophic molecules from an Indonesian medicinal plant, Zingiber purpureum. The aim of this study was to explore the neurotrophic effects of Comp.1 and Comp.2 in vitro and in vivo. Comp.1 (10-30 μM) or Comp.2 (30 μM) significantly induced neurite sprouting in PC12 cells. Comp.1 (0.03-3 μM) or Comp.2 (0.3-3 μM) significantly increased the neurite length and number of neurites in primary cultured rat cortical neurons. Comp.1 (30 μM) and Comp.2 (3-30 μM) also provided significant protection against cell death caused by deprivation of serum. The in vivo effects of both Comp.1 and Comp.2 were evaluated on hippocampal neurogenesis in olfactory bulbectomized (OBX) mice, an experimental depression and dementia animal model. Comp.1 (50mg/kg p.o.), Comp.2 (50mg/kg p.o.), or fluoxetine (10mg/kg i.p.), an antidepressant, were administrated once a day on days 15-28 after OBX. Neurogenesis was assessed by analysis of cells expressing NeuN, a neuronal marker, and 5-bromo-2'-deoxyuridine (BrdU) uptake. Immunohistochemical analys...Continue Reading

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Citations

Oct 2, 2015·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Miwa Kubo
May 12, 2020·Frontiers in Chemistry·Kenichi HaradaYoshiyasu Fukuyama
Jul 9, 2020·International Journal of Molecular Sciences·Kazumi HiranoMasakazu Namihira
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ah-Reum HanEun Kyoung Seo
Nov 26, 2013·Journal of Natural Products·Song Wha ChaeHwa Jeong Lee
Mar 20, 2013·Journal of Natural Products·Miwa KuboYoshiyasu Fukuyama

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