Phenylglycine derivatives as antagonists of metabotropic glutamate receptors

Trends in Pharmacological Sciences
J Watkins, G Collingridge


Metabotropic glutamate receptors represent a family of G protein-coupled receptors that can be activated by L-glutamate, the principal excitatory neurotransmitter in the brain. Until recently, progress in identifying the physiological and pathological roles of metabotropic glutamate receptors has been hampered by the lack of selective antagonists. In this article, Jeff Watkins and Graham Collingridge describe the pharmacology of, and initial physiological studies using, certain phenylglycine derivatives and related substances--the first definitive antagonists of metabotropic glutamate receptors.


Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J P PinS F Heinemann
Mar 22, 1991·Proceedings. Biological Sciences·S Charpak, B H Gähwiler
Jan 1, 1991·Trends in Pharmacological Sciences·M R TotaC D Strader
Dec 1, 1990·Trends in Pharmacological Sciences·D SchoeppF Sladeczek
Sep 21, 1990·European Journal of Pharmacology·A J IrvingG L Collingridge
Aug 3, 1989·European Journal of Pharmacology·E PalmerC W Cotman
Mar 15, 1994·European Journal of Pharmacology·C ThomsenP D Suzdak
Jan 1, 1993·Trends in Pharmacological Sciences·D D Schoepp, P J Conn
Jun 1, 1994·The European Journal of Neuroscience·O J ManzoniR A Nicoll
Feb 1, 1993·The European Journal of Neuroscience·S A EatonT E Salt
Jan 7, 1993·Nature·T V Bliss, G L Collingridge

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Aug 1, 1996·European Journal of Pharmacology·J S BedingfieldP J Roberts
Aug 1, 1996·European Journal of Pharmacology·M C KempP J Roberts
Jul 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·G RiedelK G Reymann
Dec 1, 1995·Progress in Neurobiology·H F Bradford
Jan 26, 1996·Neuroscience Letters·S M FitzjohnG L Collingridge
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