PMID: 3768369Nov 6, 1986Paper

Phenylhydrazine-induced changes in erythrocyte membrane surface lipid packing

Biochimica Et Biophysica Acta
A ArduiniA Stern

Abstract

Phenylhydrazine-induced oxidative damage in red cells results in increased binding of merocyanine 540, a fluorescence probe sensitive to changes in lipid packing. Fluorescence polarization studies with diphenylhexatriene did not reveal major changes in order parameters both in intact red cells and lysates treated with phenylhydrazine. These fluorescence studies indicate that major changes are observed in membrane lipids. Analytical studies of membrane phospholipids revealed a significant decrease in phosphatidylethanolamine. The results of the fluorescence and lipid studies, taken in association with our previously reported findings on spectrin and other cytoskeletal protein degradation in red cells exposed to phenylhydrazine, suggests that degradation of cytoskeleton membrane proteins is also responsible for changes in the lipid bilayer surface of the red cell membrane.

References

Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·F Jähnig
Dec 15, 1978·Biochimica Et Biophysica Acta·M Shinitzky, Y Barenholz
Jan 1, 1979·Annual Review of Biochemistry·J A Op den Kamp
Dec 14, 1979·The Journal of Membrane Biology·V T Marchesi
May 4, 1978·Biochimica Et Biophysica Acta·C W HaestB Deuticke
Jan 1, 1985·Advances in Enzyme Regulation·E Cadenas, H Sies
Dec 15, 1985·Biochemical Pharmacology·A Arduini, A Stern
Jul 25, 1984·Biochimica Et Biophysica Acta·S G Sullivan, A Stern
Jul 27, 1983·Biochimica Et Biophysica Acta·P WilliamsonR A Schlegel
Feb 1, 1981·Molecular and Cellular Biology·P L WilliamsonR A Schlegel
Jan 12, 1981·FEBS Letters·L L van Deenen
Jun 1, 1981·The Journal of Clinical Investigation·B LubinL L Van Deenen
Jun 1, 1981·Biochemical and Biophysical Research Communications·C Rice-Evans, P Hochstein
May 1, 1980·Archives of Biochemistry and Biophysics·S K Jain, P Hochstein
Nov 1, 1966·Lipids·J H WilliamsR F Witter

❮ Previous
Next ❯

Citations

Dec 1, 1992·Calcified Tissue International·R Bracci
Dec 1, 1987·Photochemistry and Photobiology·F Sieber
Feb 13, 1989·Biochimica Et Biophysica Acta·A ArduiniG Federici
Aug 15, 1989·Archives of Biochemistry and Biophysics·A ArduiniG Federici
May 7, 1991·Biochimica Et Biophysica Acta·H R PettyZ Zheng
May 8, 2020·Journal of Applied Physiology·William H NugentBjorn K Song
Nov 25, 2000·The International Journal of Biochemistry & Cell Biology·M KarbownikD Tan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.