PMID: 9159498Apr 25, 1997Paper

Phenytoin and carbamazepine: differential inhibition of sodium currents in small cells from adult rat dorsal root ganglia

Neuroscience Letters
A M Rush, J R Elliott

Abstract

We determined the effects of carbamazepine and phenytoin, anticonvulsant drugs used to treat neuropathic pain, on the heterogeneous population of Na+ channels in patch-clamped small cells from adult rat dorsal root ganglia. Both fast tetrodotoxin-sensitive (TTX-S) and slow TTX-resistant (TTX-R) currents were inhibited by 10-100 microM drug. TTX-R currents were divided into two classes. Control type I currents had a very depolarized voltage for 50% availability (Vh) of ca. -29 mV and 17% reduction in current by the 20th pulse at 1 Hz. Control type II currents had a Vh closer to -46 mV and 49% reduction in current at 1 Hz. At 0.1 Hz, which gave relatively little loss of control current, 100 microM drug caused 53 +/- 4% (n = 5) block of type I current and 88 +/- 2% inhibition of type II current (n = 4). Strong 1 s hyperpolarizing prepulses relieved most of the fast channel block but had much less effect on blocked TTX-R channels.

Citations

Aug 4, 2004·Pflügers Archiv : European journal of physiology·Hiroshi MaruyamaNobukuni Ogata
Jun 28, 2005·Pflügers Archiv : European journal of physiology·Andreas LefflerTheodore R Cummins
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