Phenytoin Cream for the Treatment for Neuropathic Pain: Case Series

Pharmaceuticals
David J Kopsky, Jan M Keppel Hesselink

Abstract

Neuropathic pain can be disabling, and is often difficult to treat. Within a year, over half of all patients stop taking their prescribed neuropathic pain medication, which is most probably due to side effects or disappointing analgesic results. Therefore, new therapies are needed to alleviate neuropathic pain. As such, topical analgesics could be a new inroad in the treatment of neuropathic pain. In 2014, we developed a new topical formulation containing either phenytoin or sodium phenytoin. After optimization of the formulation, we were able to reach a 10% concentration and combine phenytoin with other co-analgesics in the same base cream. To describe a series of 70 neuropathic pain patients who were treated with phenytoin cream. Cases treated with phenytoin 5% or 10% creams were gathered. The mean onset of pain relief, the duration of effect, and reduction in pain intensity measured on the 11-point numerical rating scale (NRS) were all studied. A single-blind response test with phenytoin 10% and placebo creams was conducted on 12 patients in order to select responders prior to prescribing the active cream. Plasma phenytoin concentrations were measured in 16 patients. Nine patients applied phenytoin 5% cream, and 61 patients ...Continue Reading

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References

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May 13, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jan M Keppel Hesselink, David J Kopsky

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Citations

Jul 26, 2018·Expert Opinion on Pharmacotherapy·Terence J Coderre
Nov 15, 2018·Pharmaceuticals·David J Kopsky, Jan M Keppel Hesselink
Mar 3, 2020·Journal of Pain & Palliative Care Pharmacotherapy·Alan L RussellJan M Keppel Hesselink
May 3, 2019·Current Pain and Headache Reports·Omar ViswanathAlan D Kaye

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