Phenytoin-induced thrombocytopenia treated with intravenous immune globulin

Journal of Pediatric Hematology/oncology
M B Salzman, E M Smith

Abstract

To describe the use of intravenous immune globulin (IVIG) in an 8-year-old girl with phenytoin-induced thrombocytopenia and leukopenia. An 8-year-old girl had fever, rash, thrombocytopenia, and leukopenia 18 days after initiation of phenytoin therapy. The phenytoin level was elevated. She was treated with 1 g/kg of IVIG. The thrombocytopenia improved dramatically after IVIG therapy. There was a slower response to the leukopenia. Phenytoin hypersensitivity can present with thrombocytopenia and leukopenia. Treatment with IVIG was associated with a rapid rise in the platelet count in the patient in this report. IVIG should be considered for patients with phenytoin-induced thrombocytopenia.

References

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Citations

Apr 17, 2001·Harefuah·R SalimE Shalev
Sep 12, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Manjari Pandey, Lavanya Yarlagadda
Apr 9, 2005·Journal of Paediatrics and Child Health·Albert M LiTai Fai Fok
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Jul 9, 2008·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Dattatreya MendhekarChittaranjan Andrade

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