Phenytoin inhibits isolation-induced aggression specifically in rats with low serotonin

Neuroreport
N Bradley Keele

Abstract

Phenytoin is a widely used anticonvulsant drug that also reduces aggressive behavior. Aggression in humans and animals is often associated with low serotonin levels. This study examined the anti-aggressive properties of phenytoin in rodent isolation-induced aggression using a resident-intruder test to quantify aggression. Chronic treatment with p-chlorophenyl-alanine (PCPA), a competitive inhibitor of serotonin synthesis, significantly enhanced resident attack behavior compared to saline-treated control rats. Phenytoin dose-dependently reduced aggressive behavior specifically in PCPA-treated rats, but had no anti-aggressive properties in saline-treated rats. These data suggest that aggressive behavior in this model may be related to neuronal hyperexcitability that is sensitive to the anticonvulsant effects of phenytoin. Further, these data suggest isolation-induced aggression in PCPA-treated rats may be a useful model to investigate aggression associated with low serotonin in the brain.

References

May 1, 1975·Pharmacology, Biochemistry, and Behavior·K A MiczekW O Boggan
Oct 1, 1977·Behavioral Biology·R J Blanchard, D C Blanchard
Jan 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·B Olivier, J Mos
Jan 1, 1986·Annals of the New York Academy of Sciences·G L Brown, F K Goodwin
Nov 1, 1989·Annals of Neurology·J O McNamaraC Shin
Dec 1, 1973·Postgraduate Medical Journal·E Hitchcock, V Cairns
Jun 1, 1981·Archives of General Psychiatry·L TräskmanL Sjöstrand
Jan 1, 1980·Progress in Neurobiology·J M KoolhaasP R Wiepkema
Oct 1, 1994·The American Journal of Psychiatry·P T MehlmanM Linnoila
Jan 1, 1995·The Journal of Neuropsychiatry and Clinical Neurosciences·D BlumerB Hermann
Oct 8, 1997·Journal of Clinical Psychopharmacology·E S BarrattT A Kent
Mar 4, 1998·Neurology·M E GerardD Shantz
May 13, 1998·Psychological Review·J B Rosen, J Schulkin
Aug 7, 1998·Biological Psychiatry·I Lucki
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Jun 28, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S F de BoerJ M Koolhaas
Jul 1, 1963·Archives of Neurology·H NARABAYASHIM NAGAHATA

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