Pheochromocytoma and paraganglioma: clinical feature-based disease probability in relation to catecholamine biochemistry and reason for disease suspicion

European Journal of Endocrinology
Aikaterini GeroulaGraeme Eisenhofer

Abstract

Hypertension and symptoms of catecholamine excess are features of pheochromocytomas and paragangliomas (PPGLs). This prospective observational cohort study assessed whether differences in presenting features in patients tested for PPGLs might assist establishing likelihood of disease. Patients were tested for PPGLs because of signs and symptoms, an incidental mass on imaging or routine surveillance due to previous history or hereditary risk. Patients with (n = 245) compared to without (n = 1820) PPGLs were identified on follow-up. Differences in presenting features were then examined to assess the probability of disease and relationships to catecholamine excess. Hyperhidrosis, palpitations, pallor, tremor and nausea were 30-90% more prevalent (P < 0.001) among patients with than without PPGLs, whereas headache, flushing and other symptoms showed little or no differences. Although heart rates were higher (P < 0.0001) in patients with than without PPGLs, blood pressures were not higher and were positively correlated to BMI, which was lower (P < 0.0001) in patients with than without PPGLs. From these differences in clinical features, a score system was established that indicated a 5.8-fold higher probability of PPGLs in patients w...Continue Reading

Citations

Aug 21, 2019·Expert Review of Endocrinology & Metabolism·Ioannis Ilias, Costas Thomopoulos
Jul 30, 2020·The Journal of Clinical Endocrinology and Metabolism·Annika M A BerendsHenri J L M Timmers
Sep 29, 2020·AACE Clinical Case Reports·Georgiana ConstantinescuJacques Lenders
Oct 2, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Graeme EisenhoferMercedes Robledo
Dec 21, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·K LangtonJwm Lenders
Mar 2, 2021·Deutsche medizinische Wochenschrift·Carmina Teresa FussMartin Fassnacht
May 8, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R Garcia-CarboneroF A Hanzu
May 2, 2021·Journal of Cardiothoracic and Vascular Anesthesia·David Keegan StombaughMichiel N Kerstens
Jul 17, 2021·The British Journal of Surgery·L Hallin ThompsonUNKNOWN Eurocrine Council
Jun 20, 2021·Endocrine Reviews·Svenja NöltingKarel Pacak
Nov 27, 2021·Deutsche medizinische Wochenschrift·Hanna Remde, Svenja Nölting
Nov 28, 2021·Journal of Personalized Medicine·Bettina WinzelerRuth T Casey

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