Pheomelanin coat colour dilution in French cattle breeds is not correlated with the TYR, TYRP1 and DCT transcription levels

Pigment Cell Research
Sylvain GuibertAhmad Oulmouden

Abstract

In this study we report the isolation of full-length cDNAs and the expression patterns of TYR, TYRP1 and DCT in four e/e cattle breeds exhibiting different pheomelanic coat colours ranging from reddish brown to creamy white phenotypes. Predicted proteins encoded by bovine TYR, TYRP1 and DCT display high levels of homology and contain all characteristic domains shared between their mouse and human counterparts. The full expression of these three genes is observed in melanocytes of black areas of E(D)/E(D) Prim'Holstein's animals. On the other hand, e/e melanocytes of animals belonging to the Blonde d'Aquitaine (blond), Limousine (red) and Salers (reddish brown) breeds present different levels of down-regulated TYR and DCT expression and a complete repression of TYRP1. Surprisingly, e/e melanocytes of animals belonging to the Charolais breed (creamy white) present an inverse relationship between TYR, TYRP1 and DCT expression and its lower melanogenic activity. The sum of these results shows that the dilution of the coat colour in French cattle breeds is not correlated with a transcription level of TYR family genes. Other possible modifier loci are suggested.

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Citations

Jun 3, 2014·BMC Complementary and Alternative Medicine·Adila TuerxuntayiHaji Akber Aisa
Oct 9, 2012·The International Journal of Biochemistry & Cell Biology·Fengfeng PingLuyong Zhang
Jan 15, 2005·Pigment Cell Research·Michael GirardotAhmad Oulmouden
Jul 12, 2005·Peptides·Francois Rouzaud, Vincent J Hearing
Aug 16, 2014·Animal Science Journal = Nihon Chikusan Gakkaihō·Artur GurgulMonika Bugno-Poniewierska
Apr 10, 2013·Seminars in Cell & Developmental Biology·Anna Linderholm, Greger Larson
Aug 22, 2017·Asian-Australasian Journal of Animal Sciences·Hasina SultanaJun-Heon Lee
Oct 5, 2017·Hereditas·Bei LiDugarjaviin Manglai

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