Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis

Pigment Cell Research
Tomohisa HirobeShosuke Ito

Abstract

The present study was designed to clarify the role of the agouti gene in the regulation of the proliferation and differentiation of mouse epidermal melanocytes using serum-free primary culture of epidermal melanocytes from 0.5-d-old black (a/a; C57BL/10JHir) mice and congenic, agouti (A/A; C57BL/10JHir-A/A) mice. There was no significant difference in the proliferation or differentiation of melanocytes between a/a and A/A mice. However, the content of pheomelanin in culture media from A/A melanocytes was increased by L-tyrosine compared with a/a melanocytes. In addition, the content of the pheomelanin precursor, 5-S-cysteinyldopa, in culture media from A/A melanocytes was dramatically increased by L-tyrosine. Moreover, pheomelanin content in the epidermis from 3.5- and 5.5-d-old A/A mice was much higher than in a/a mice. Analysis of the A gene using reverse transcription-polymerase chain reaction revealed that cultured keratinocytes and melanocytes do not express the A gene. Moreover, the A gene was expressed in the A/A dermis of 0.5-, 3.5- and 5.5-d-old mice, but not in the a/a dermis nor in the A/A or a/a epidermis. These results suggest that A/A epidermal melanoblasts are influenced by the A gene from the dermis of neonatal ...Continue Reading

References

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Aug 14, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E V SviderskayaD C Bennett
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Citations

Jul 23, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sreenivasulu ChintalaRichard T Swank
Jul 6, 2007·The Journal of Investigative Dermatology·Roman J GarciaLidia Kos
Mar 8, 2011·Pigment Cell & Melanoma Research·Tomohisa Hirobe

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