PMID: 7537528Mar 1, 1995Paper

Philadelphia-chromosome-negative peripheral blood stem cells can be mobilized in the early phase of recovery after a myelosuppressive chemotherapy in Philadelphia-chromosome-positive acute lymphoblastic leukaemia

British Journal of Haematology
A M CarellaF Benvenuto

Abstract

Ten patients in first or second relapse with Philadelphia chromosome acute lymphoblastic leukaemia, ineligible for allogeneic sibling marrow transplantation, were treated with an intensive chemotherapy regimen including idarubicin, intermediate-dose arabinosylcytosine, etoposide and G-CSF. Peripheral blood stem cells were collected by leukapheresis during initial early WBC recovery from chemotherapy-induced aplasia. In 5/10 patients all metaphases in leukapheresis products were found to be Philadelphia-chromosome-negative and they have been used as autotransplants after conditioning with TBI/etoposide/cyclophosphamide (or idarubicin) and G-CSF. All five patients showed sustained engraftment and one of them is alive and well Philadelphia-chromosome-negative 18 months after transplant. These preliminary results suggest that it is possible to recover Philadelphia-chromosome-negative blood stem cells after intensive chemotherapy, even in advanced patients, and to perform autografting with these cells.

References

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Citations

May 29, 1998·Journal of Clinical Pathology·I O Singer, I M Franklin
Feb 18, 2016·Stem Cells International·José Eugenio Vázquez MerazElva Jiménez-Hernández
Jun 9, 2004·Critical Reviews in Oncology/hematology·Renato BassanRoel Willemze
Jan 24, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Prakash SatwaniMitchell S Cairo
Nov 25, 1997·Blood Reviews·A M CarellaF Frassoni
Mar 13, 2014·Expert Review of Anticancer Therapy·Elena MainoRenato Bassan

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