Philadelphia-positive T-cell acute lymphoblastic leukemia with polymyositis, migratory polyarthritis and hypercalcemia following a chronic myeloid leukemia

Annals of Hematology
M LimaB Justiça

Abstract

Transformation of chronic myeloid leukemia (CML) often results in acute myeloblastic or, less frequently, in precursor B-cell acute lymphoblastic leukemia (ALL). T-cell blast crisis is rare. Hypercalcemia has also been described as a rare complication of CML, but this usually occurs as a terminal event. Here we report a case of a 35-year-old woman who developed a CD4(+)/CD8(+) T-cell ALL 2 years after the diagnosis of a typical Ph(+) CML. Polymyositis and polyarthritis preceded by 4 months, and symptomatic hypercalcemia occurred just before blastic transformation, probably representing paraneoplastic manifestations of the disease.

Citations

Jun 20, 2008·Rheumatology International·Jia-Kun ShenJie Jin
May 28, 2009·Rheumatology International·Ankit ShrivastavJyotirmoy Pal
Mar 1, 2004·Journal of Clinical Neuromuscular Disease·Jayashri SrinivasanAnthony A Amato
Jul 10, 2004·Journal of the American Academy of Dermatology·Yorick SandbergFreerk Heule
Oct 9, 2019·Journal of Medical Case Reports·Mickael EssoumaGloria E Ashuntantang
Sep 11, 2018·Journal of Medical Case Reports·Pongprueth RujirachunSirinart Sirinvaravong
Feb 28, 2017·The American Journal of Case Reports·David Toro-TobónJan M Bruder

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