Philosophy of voltage-gated proton channels.

Journal of the Royal Society, Interface
Thomas E DeCoursey, Jonathan Hosler

Abstract

In this review, voltage-gated proton channels are considered from a mainly teleological perspective. Why do proton channels exist? What good are they? Why did they go to such lengths to develop several unique hallmark properties such as extreme selectivity and ΔpH-dependent gating? Why is their current so minuscule? How do they manage to be so selective? What is the basis for our belief that they conduct H(+) and not OH(-)? Why do they exist in many species as dimers when the monomeric form seems to work quite well? It is hoped that pondering these questions will provide an introduction to these channels and a way to logically organize their peculiar properties as well as to understand how they are able to carry out some of their better-established biological functions.

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Citations

Jun 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Amaury Pupo, Carlos Gonzalez León
Aug 25, 2016·Nature Chemistry·Bridget SalnaPaul M Champion
Aug 3, 2016·The Journal of General Physiology·Thomas E DeCourseyVladimir V Cherny
Sep 13, 2016·Journal of the American Chemical Society·Todor DudevCarmay Lim
Aug 5, 2017·Physiological Reports·Adisorn RatanayothaYasushi Okamura
Jun 21, 2014·Nature Chemistry·Marco Rolandi
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May 9, 2015·Scientific Reports·Todor DudevCarmay Lim
Aug 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Richard BanhThomas E DeCoursey
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Apr 14, 2021·Nano Letters·Zhiyang ZengLuda Wang
Jul 3, 2021·Frontiers in Chemistry·Divya KaurM R Gunner

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