PMID: 6983053Sep 1, 1982Paper

Phloretin sensitive active urea absorption in frog skin

Pflügers Archiv : European journal of physiology
M SveltoC Lippe

Abstract

This report presents evidence for urea active absorption by isolated skin of Rana esculenta. One of the supporting factors of such evidence is that at a low concentration the urea influx is five times greater than the outflux, in the absence of a chemical gradient. The transport shows a saturation kinetics with an apparent Km = 1.33 mM and is inhibited by un uncoupling agent (FCCP). 5 x 10(-4) M Phloretin, added to the external side, markedly inhibits inward urea transport, whereas it is ineffective when added to the serosal fluid. This provides evidence for a phloretin-sensitive mechanism located at the external side of the epithelium. Phloretin stimulates the sodium active transport; the possible coupling of urea and sodium movement is analysed.

References

May 1, 1977·The Journal of General Physiology·S I Helman, R S Fisher
Mar 30, 1976·Pflügers Archiv : European journal of physiology·S CurciC Lippe
Jun 1, 1973·The Journal of Clinical Investigation·S LevineR M Hays
Jan 1, 1967·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·K J UllrichB Schmidt-Nielsen
May 1, 1970·The American Journal of Physiology·B Schmidt-Nielsen, R R Robinson
Jul 7, 1970·Biochimica Et Biophysica Acta·R I Macey, R E Farmer
Jun 1, 1966·The American Journal of Physiology·J R Clapp
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Sep 1, 1964·Biophysical Journal·C R HOUSE
Apr 1, 1960·The Journal of Clinical Investigation·R H MAFFLYA LEAF
Oct 1, 1959·The American Journal of Physiology·B SCHMIDT-NIELSEN, R O'DELL

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Citations

Mar 20, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J Ehrenfeld
Jun 1, 1985·Archives internationales de physiologie et de biochimie·C Ardizzone, C Lippe
Jul 2, 2004·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Patricia WrightYuen Kwong Ip

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