Phloroglucinol as an adjuvant analgesic to treat renal colic

The American Journal of Emergency Medicine
Hamdi BoubakerSemir Nouira

Abstract

We tested whether the addition of phloroglucinol to piroxicam could improve pain relief in patients with acute renal colic visiting the emergency department. Patients with a diagnosis of acute renal colic were prospectively randomized to receive intravenous phloroglucinol (200 mg) or placebo combined with intramuscular piroxicam (20 mg). We monitored the visual analogic scale (VAS), heart rate, arterial blood pressure, need for rescue therapy, and adverse events at different time points for 1 hour. We recorded admission requirement and new visit at 72 hours for renal colic. The primary end point was to assess pain relief at 1 hour, defined as a decrease of 50% or more as compared with the initial VAS. The secondary objectives were to compare the 2 groups for VAS at any time points, the need for rescue therapy, and the occurrence of adverse events. Of the 309 eligible patients, 253 entered the study. A total of 126 patients received phloroglucinol and 127 patients received placebo. Pain relief at 1 hour was obtained in 89 patients (71%) receiving phloroglucinol and 89 patients (70%) receiving placebo (P = .89). There were no differences in VAS between the 2 groups at any time points. Rescue therapy was required in 37 patients (2...Continue Reading

References

Jun 21, 2005·BJU International·Amrith Raj Rao, Roger O Plail
Jul 12, 2005·The Journal of Urology·Anna Holdgate, Carissa M Oh
Sep 28, 2007·Scandinavian Journal of Urology and Nephrology·D S EngelerH P Schmid

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Citations

Apr 5, 2014·Anesthesiology and Pain Medicine·Samad Ej GolzariHanieh Ebrahimi Bakhtavar
Jun 30, 2015·The Cochrane Database of Systematic Reviews·Kourosh AfsharAndrew E MacNeily

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