Abstract
To evaluate whether phobic anxiety is associated with increased risk of cardiac mortality in individuals with established coronary heart disease (CHD) and to examine the role of reduced heart rate variability (HRV) in mediating this risk. Previous findings suggest that phobic anxiety may pose increased risk of cardiac mortality in medically healthy cohorts. We performed a prospective cohort study in 947 CHD patients recruited during hospitalization for coronary angiography. At baseline, supine recordings of heart rate for HRV were collected, and participants completed the Crown-Crisp phobic anxiety scale. Fatal cardiac events were identified over an average period of 3 years. Female CHD patients reported significantly elevated levels of phobic anxiety when compared with male patients (p < .001), and survival analysis showed an interaction between gender and phobic anxiety in the prediction of cardiac mortality (p = .058) and sudden cardiac death (p = .03). In women, phobic anxiety was associated with a 1.6-fold increased risk of cardiac mortality (hazard ratio, 1.56; 95% confidence interval, 1.15-2.11; p = .004) and a 2.0-fold increased risk of sudden cardiac death (hazard ratio, 2.02; 95% confidence interval, 1.16-3.52; p = .0...Continue Reading
References
Sep 1, 1978·The British Journal of Medical Psychology·A H CrispP Slater
Jun 1, 1990·Acta Psychiatrica Scandinavica·V K YeraganiB Merlos
Aug 1, 1987·British Medical Journal·A P HainesT W Meade
Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonC R MacKenzie
Sep 1, 1966·The British Journal of Psychiatry : the Journal of Mental Science·S Crown, A H Crisp
Oct 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·M Mavissakalian, L Michelson
May 1, 1995·The American Journal of Cardiology·I KawachiS T Weiss
May 1, 1994·Archives of General Psychiatry·H U WittchenW W Eaton
May 1, 1994·Circulation·I KawachiW C Willett
Jan 1, 1993·Psychiatry Research·V K YeraganiP Weinberg
Feb 1, 1996·Archives of General Psychiatry·W J MageeR C Kessler
Feb 15, 1996·Biological Psychiatry·J F ThayerT D Borkovec
Mar 1, 1997·Biological Psychiatry·H CohenY Cassuto
Apr 1, 1997·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·P A LowP C O'Brien
Aug 26, 1998·Psychosomatic Medicine·L L WatkinsA Sherwood
Nov 10, 1998·Journal of Medical Engineering & Technology·S CarrascoJ Azpiroz
Sep 6, 2002·Psychophysiology·Nicholas D GiardinoRobert Edelberg
Jul 2, 2003·Journal of Applied Physiology·Paula S McKinleyRichard P Sloan
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Feb 3, 2005·Circulation·Christine M AlbertIchiro Kawachi
Jun 9, 2005·Archives of General Psychiatry·Ronald C KesslerEllen E Walters
Jun 9, 2005·Archives of General Psychiatry·Ronald C KesslerEllen E Walters
Oct 3, 2006·Psychosomatic Medicine·Lana L WatkinsMichael H Sketch
Oct 2, 2007·Statistics in Medicine·Andrew J VickersEwout Steyerberg
Oct 3, 2007·Archives of General Psychiatry·Jordan W SmollerDavid Sheps
Citations
Nov 10, 2011·Psychological Medicine·M Di SimplicioC J Harmer
Sep 5, 2012·Trials·Angelo CompareMichele Carenini
Jun 2, 2011·Future Cardiology·Riccardo ProiettiLuciano Daliento
Nov 5, 2013·Brain, Behavior, and Immunity·Maryam S FarvidWalter C Willett
Oct 23, 2012·Journal of Behavioral Medicine·Janine Giese-DavisDavid Spiegel
Dec 3, 2014·The American Journal of Cardiology·William WhangDaichi Shimbo
Sep 7, 2013·Women's Health·Eileen M HandbergThomas R Rutledge
Aug 10, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Isabelle CarrièreMarie Laure Ancelin
Sep 6, 2011·Revista española de cardiología·Patrick J Smith, James A Blumenthal
Dec 19, 2015·American Heart Journal·Christopher M CelanoJeff C Huffman
Jan 16, 2014·Psychophysiology·Madelein T HoogwegtNina Kupper
Oct 29, 2015·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Karni GinzburgAvi Bleich
Feb 16, 2013·International Journal of Cardiology·Thomas RutledgeC Noel Bairey Merz
Jan 7, 2017·Geriatrics & Gerontology International·Hsiao-Ting ChangPesus Chou
Jul 24, 2015·Genetic Epidemiology·Abanish SinghRedford B Williams
Jan 1, 2016·Terapevticheskiĭ arkhiv·F I Belialov
Oct 27, 2010·Nature Reviews. Cardiology·James A Blumenthal, Patrick J Smith
Sep 4, 2021·Tissue Engineering. Part B, Reviews·Tori SalemJared M Churko