Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation.

FEBS Letters
Mi Ran ByunJeong-Ho Hong

Abstract

Osteoporosis arises from an imbalance between osteoblastic bone formation and osteoclastic bone resorption. In this study, we screened molecules from marine natural products that stimulate osteoblast differentiation. We found that phorbaketal A significantly stimulates osteoblast differentiation in mesenchymal cells. Increased interaction of TAZ and Runx2 stimulated phorbaketal A-induced expression of osteoblastic marker genes. The activation of ERK was important for the stimulation of differentiation because an inhibitor of ERK blocked phorbaketal A-induced osteogenic differentiation. Taken together, the results showed that phorbaketal A stimulates TAZ-mediated osteoblast differentiation through the activation of ERK.

References

Feb 8, 2000·The Journal of Biological Chemistry·G XiaoR T Franceschi
Jul 13, 2002·Trends in Molecular Medicine·Xiangli Yang, Gerard Karsenty
Aug 7, 2003·Trends in Genetics : TIG·Kazuhisa Nakashima, Benoit de Crombrugghe
Feb 19, 2004·The Journal of Biological Chemistry·Kwon-Sik ParkMariastella Zannini
Mar 24, 2005·Journal of Cellular Biochemistry·Toshihisa Komori
Aug 16, 2005·Science·Jeong-Ho HongMichael B Yaffe
Nov 23, 2005·Biochemical and Biophysical Research Communications·Masao MurakamiHiroki Kurihara
Dec 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Masao MurakamiOsamu Nakagawa
Jan 30, 2008·Molecular and Cellular Biology·Qun-Ying LeiKun-Liang Guan
Jun 24, 2008·Nature Cell Biology·Xaralabos VarelasJeffrey L Wrana
Nov 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tetsuya MatsuguchiTomokazu Ohnishi
Dec 23, 2008·Nature Clinical Practice. Rheumatology·Chad Deal
Mar 28, 2009·The Journal of Biological Chemistry·Siew Wee ChanWanjin Hong
Mar 28, 2009·The Journal of Biological Chemistry·Heng ZhangKun-Liang Guan
Dec 17, 2009·The Journal of Biological Chemistry·Ok-Jin ParkHyun-Mo Ryoo
Mar 9, 2010·Current Molecular Medicine·R TrivediN Chattopadhyay
May 15, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hana JeongEun Sook Hwang
May 5, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hui LiuScott D Boden

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Citations

Feb 27, 2013·PloS One·Jae-Yeon YangChan Soo Shin
Jul 15, 2015·The International Journal of Biochemistry & Cell Biology·Jie FengDa Xing
Jul 25, 2015·International Journal of Oral Science·Dian JingZhi-He Zhao
Feb 7, 2015·The Journal of Organic Chemistry·Jonathan G HubertMargaret A Brimble
Oct 26, 2012·Organic Letters·Mengyang XuanStephen M Dalby
Jul 7, 2017·Organic Letters·Seewon JoungHee-Yoon Lee
Mar 17, 2018·Natural Product Reports·Harry J ShirleyChristopher D Bray
Aug 25, 2018·Organic & Biomolecular Chemistry·Saumitra Sengupta, Goverdhan Mehta
Sep 15, 2018·Natural Product Reports·Yuye ChenJing Xu
Jul 11, 2019·Organic & Biomolecular Chemistry·Harry J Shirley, Christopher D Bray
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Boon C HengXuliang Deng
May 16, 2019·Stem Cells International·Aofei YangChengjian He
Sep 21, 2018·Marine Drugs·Matthew A Carson, Susan A Clarke
Apr 24, 2021·Biomacromolecules·Kajal ChakrabortyShubhajit Dhara

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