Phorbaketals A, B, and C, sesterterpenoids with a spiroketal of hydrobenzopyran moiety isolated from the marine sponge Phorbas sp

Organic Letters
Jung-Rae RhoHyeon-Jin Kim

Abstract

Three new sesterterpenoids, phorbaketals A (1), B (2), and C (3) which have a spiroketal of the hydrobenzopyran moiety, were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral and chemical methods. They exhibited moderate cytotoxicity against human colorectal, hepatoma, and lung cancer cell lines. Furthermore, the cultivation of the bacterial fraction from the sponge afforded compound 1.

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Citations

May 9, 2012·Journal of the American Chemical Society·Jinhua HuangJiong Yang
Jan 31, 2013·Journal of Natural Products·Weihong WangHeonjoong Kang
Sep 13, 2013·Journal of Natural Products·Ju-eun JeonJongheon Shin
Oct 22, 2016·The Journal of Organic Chemistry·Meng WangRaymond J Andersen
May 16, 2014·Organic Letters·Jung-Kyun WooJongheon Shin
Jul 7, 2017·Organic Letters·Seewon JoungHee-Yoon Lee
Mar 17, 2018·Natural Product Reports·Harry J ShirleyChristopher D Bray
Aug 25, 2018·Organic & Biomolecular Chemistry·Saumitra Sengupta, Goverdhan Mehta
Sep 15, 2018·Natural Product Reports·Yuye ChenJing Xu
Jul 11, 2019·Organic & Biomolecular Chemistry·Harry J Shirley, Christopher D Bray
Dec 15, 2010·Natural Product Reports·John W BluntMichèle R Prinsep
Feb 7, 2013·Natural Product Reports·Lishu WangYonghong Liu
May 7, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Bruno S do AmaralAlessandra L Valverde
Mar 18, 2010·Journal of Natural Products·Su Young ParkJung-Rae Rho
Oct 26, 2012·Organic Letters·Mengyang XuanStephen M Dalby
Jan 31, 2015·Journal of Natural Products·Jung-Kyun WooJongheon Shin
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Aug 15, 2013·The Journal of Organic Chemistry·Julie DaoustRaymond J Andersen
Nov 29, 2013·Organic Letters·Wei-Zhong LiuRong-Xiu Zhu

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