Phorbol ester inhibition of vasopressin-induced calcium efflux from cultured rat aortic myocytes

FEBS Letters
B Lassegue, J C Stoclet

Abstract

The effect of the protein kinase C activator TPA was investigated on AVP-induced 45Ca release from rat aortic myocytes. In the nanomolar range TPA, but not 4 beta-phorbol, reduced the brief 45Ca efflux produced by AVP in the presence or in the absence of extracellular calcium. The maximal effect of TPA was to abolish the response to a half maximally active concentration of AVP, and to reduce by 50% the maximal response to the hormone. These results suggest that protein kinase C activation can exert a negative control on the early AVP-induced calcium mobilization in vascular smooth muscle.

References

Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L M Leeb-LundbergM G Caron
Aug 30, 1985·Biochemical and Biophysical Research Communications·V M Doyle, U T Rüegg
Jul 16, 1985·Biochemical and Biophysical Research Communications·H Yamamoto, C van Breemen
Apr 29, 1983·Biochemical and Biophysical Research Communications·J YamanishiY Nishizuka

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Citations

Nov 1, 1989·Molecular and Cellular Endocrinology·R SchleifferA Gairard
Jan 1, 1988·Annals of the New York Academy of Sciences·J C StocletC Lugnier
Mar 13, 1987·Biochemical and Biophysical Research Communications·C Boulanger-Saunier, J C Stoclet

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