Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) reduces vascular endothelial growth factor expression in allergen-induced airway inflammation

Molecular Pharmacology
Kyung Sun LeeYong Chul Lee

Abstract

Vascular endothelial growth factor (VEGF) plays a pivotal role in the pathogenesis of bronchial asthma. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) has been implicated in regulating cell survival signaling through the phosphoinositide 3-kinase (PI3K)/Akt pathway. The key role of PI3K in VEGF-mediated signal transduction is established. However, the effects of PTEN on VEGF-mediated signaling in asthma are unknown. This study aimed to determine the effect of PI3K inhibitors and PTEN on VEGF expression in allergen-induced airway inflammation. We have used a female C57BL/6 mouse model for asthma to determine the role of PTEN in allergen-induced airway inflammation, specifically in the expression of VEGF. Allergen-induced airway inflammation leads to increased activity of PI3K in lung tissue. These mice develop the following typical pathophysiological features of asthma in the lungs: increased numbers of inflammatory cells of the airways; airway hyper-responsiveness; increased expression of interleukin (IL)-4, IL-5, IL-13, intercellular adhesion molecule 1, vascular cell adhesion molecule 1, regulated on activation normal T cell expressed and secreted (RANTES), and eotaxin; increased vascular permeability; and inc...Continue Reading

References

Mar 1, 1991·Respiratory Medicine·S Montefort, S T Holgate
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·C G Persson
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·T C HeB Vogelstein
Dec 16, 1998·Journal of Leukocyte Biology·S DunzendorferC J Wiedermann
Apr 3, 1999·The Journal of Biological Chemistry·G D ThakkerT K Rosengart
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·L C Cantley, B G Neel
Dec 28, 1999·Annual Review of Cell and Developmental Biology·G L Semenza
Mar 31, 2000·Nature Medicine·G ThurstonG D Yancopoulos
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Jun 9, 2001·The Journal of Allergy and Clinical Immunology·M HoshinoQ A Hamid
Jun 9, 2001·The Journal of Allergy and Clinical Immunology·Y C Lee, H K Lee
Jul 4, 2001·American Journal of Respiratory and Critical Care Medicine·B E OrsidaE H Walters
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·C I EzeamuzieE Philips
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael HanniganChi-Kuang Huang
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yong C LeeChang H Song
Aug 3, 2002·Nature Immunology·Taro FukaoShigeo Koyasu
Sep 6, 2002·Biochemical Pharmacology·Gregg Semenza
Oct 10, 2002·The Journal of Allergy and Clinical Immunology·Ajay B AntonyKamal A Mohammed
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yun-Jin JungLen Neckers
Nov 11, 2003·American Journal of Respiratory Cell and Molecular Biology·Clemens FeistritzerChristian J Wiedermann
Feb 3, 2005·International Immunopharmacology·Wei DuanW S Fred Wong

❮ Previous
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Citations

Mar 22, 2013·International Journal of Colorectal Disease·Zhi LiHua Tian Gan
Sep 25, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Seoung J ParkYong C Lee
Mar 27, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Hee Sun ParkYong Chul Lee
Jul 17, 2007·Biochemistry. Biokhimii︠a︡·V I Kulinsky
Jun 5, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Katerina VaporidiDimitris Iliopoulos
May 8, 2009·Clinical and Molecular Allergy : CMA·Amrendra Kumar, Balaram Ghosh
Jan 23, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yin-Yin HuangDe-Xiang Xu
May 14, 2009·Journal of Gastroenterology·Motoki TakashimaRichard A Rippe
Jan 30, 2010·In Vitro Cellular & Developmental Biology. Animal·Shimon LechtPeter I Lelkes
Oct 17, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Mei YuanJian Xia
Mar 8, 2016·The Journal of Allergy and Clinical Immunology·Valerie HoxJoshua D Milner
Oct 30, 2009·The Journal of Allergy and Clinical Immunology·So Ri KimYong Chul Lee
Apr 18, 2007·Journal of Endodontics·Leticia Grando MattuellaAnna Christina Medeiros Fossati
May 17, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Rob VandebrielHenk van Loveren
May 14, 2014·The International Journal of Biochemistry & Cell Biology·Xin QiXiang Gao
Jul 25, 2009·Respiratory Medicine·H Dean HosgoodQing Lan
Feb 2, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rafael Pulido
Aug 2, 2008·Immunopharmacology and Immunotoxicology·So Ri Kim, Yong Chul Lee
Jun 3, 2010·Circulation·Chun-Mei CaoRui-Ping Xiao
Oct 6, 2006·The Journal of Pharmacology and Experimental Therapeutics·Kazuhiro ItoIan M Adcock
Dec 13, 2007·The Journal of Biological Chemistry·Stephanie J HarrisStephen G Ward
May 3, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nam-In KangHern-Ku Lee
Jun 19, 2014·Experimental and Therapeutic Medicine·Junfei WangLiang Dong
May 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marc R J CarlsonTimothy F Cloughesy

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