Phosphate homeostasis and its role in bone health.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Maria Goretti Penido, Uri S Alon

Abstract

Phosphate is one of the most abundant minerals in the body, and its serum levels are regulated by a complex set of processes occurring in the intestine, skeleton, and kidneys. The currently known main regulators of phosphate homeostasis include parathyroid hormone (PTH), calcitriol, and a number of peptides collectively known as the "phosphatonins" of which fibroblast growth factor-23 (FGF-23) has been best defined. Maintenance of extracellular and intracellular phosphate levels within a narrow range is important for many biological processes, including energy metabolism, cell signaling, regulation of protein synthesis, skeletal development, and bone integrity. The presence of adequate amounts of phosphate is critical for the process of apoptosis of mature chondrocytes in the growth plate. Without the presence of this mineral in high enough quantities, chondrocytes will not go into apoptosis, and the normal physiological chain of events that includes invasion of blood vessels and the generation of new bone will be blocked, resulting in rickets and delayed growth. In the rest of the skeleton, hypophosphatemia will result in osteomalacia due to an insufficient formation of hydroxyapatite. This review will address phosphate metabo...Continue Reading

References

Feb 15, 2001·American Journal of Physiology. Cell Physiology·H XuF K Ghishan
Feb 8, 2002·American Journal of Physiology. Cell Physiology·Hua XuFayez K Ghishan
Mar 7, 2002·The Journal of Biological Chemistry·Hiroko SegawaKen-Ichi Miyamoto
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kayo ArimaFayez K Ghishan
May 17, 2003·Pflügers Archiv : European journal of physiology·Heini MurerJürg Biber
Aug 2, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hua XuFayez K Ghishan
Aug 22, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D MagneJ Guicheux
Feb 18, 2004·The Journal of Clinical Investigation·Takashi ShimadaTakeyoshi Yamashita
Mar 5, 2004·American Journal of Physiology. Renal Physiology·Hiroko SegawaKen-ichi Miyamoto
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Olivier DardenneRené St-Arnaud
Nov 25, 2004·American Journal of Physiology. Renal Physiology·Hiroko SegawaKen-ichi Miyamoto
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yves SabbaghMarie B Demay
Jul 7, 2005·American Journal of Physiology. Renal Physiology·Takashi ShimadaTakeyoshi Yamashita
Jul 14, 2005·Annual Review of Nutrition·Harriet S Tenenhouse
Jul 16, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Olga I KolekFayez K Ghishan
Nov 9, 2005·American Journal of Physiology. Renal Physiology·Theresa J BerndtRajiv Kumar
Feb 2, 2006·American Journal of Physiology. Endocrinology and Metabolism·Shiguang LiuL Darryl Quarles
Jun 1, 2006·The Journal of Clinical Endocrinology and Metabolism·Diana M AntoniucciAnthony A Portale
Aug 26, 2006·Nature Clinical Practice. Nephrology·Jamshid Amanzadeh, Robert F Reilly
Nov 7, 2006·Nature·Itaru UrakawaTakeyoshi Yamashita
Mar 14, 2007·Bone·Yuji YoshikoNorihiko Maeda
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Theresa BerndtRajiv Kumar
Feb 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hua WangNorihiko Maeda
Feb 22, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aisha ShaikhRajiv Kumar
Sep 2, 2008·Pflügers Archiv : European journal of physiology·J BiberH Murer
Dec 6, 2008·Journal of the American Society of Nephrology : JASN·Hiroko SegawaKen-Ichi Miyamoto
Dec 17, 2008·American Journal of Physiology. Renal Physiology·Ricardo Villa-BellostaIan C Forster
Feb 5, 2009·Kidney International·Dominique PriéGérard Friedlander
Jun 9, 2009·Journal of Bone and Mineral Metabolism·Dov Tiosano, Ze'ev Hochberg
Jul 25, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Makoto Kuro-o
Aug 12, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jyothsna Gattineni, Michel Baum
Aug 14, 2009·American Journal of Physiology. Renal Physiology·Hector GiralMoshe Levi
Sep 25, 2009·European Journal of Endocrinology·Isolde RamonRafik Karmali
Oct 21, 2009·Pflügers Archiv : European journal of physiology·Ricardo Villa-Bellosta, Víctor Sorribas
Dec 17, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Katherine Wesseling-Perry
Jan 12, 2010·Annual Review of Medicine·Clemens Bergwitz, Harald Jüppner
Feb 24, 2010·Nature Reviews. Nephrology·Emily G Farrow, Kenneth E White
Apr 1, 2010·Pflügers Archiv : European journal of physiology·Sonja C ReiningNati Hernando
Jun 8, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Justin Silver, Tally Naveh-Many
Jun 11, 2010·American Journal of Physiology. Renal Physiology·Joanne MarksRobert J Unwin
Oct 7, 2010·Nature Reviews. Nephrology·Amir S Alizadeh Naderi, Robert F Reilly
Jan 5, 2011·European Journal of Pediatrics·Uri S Alon

❮ Previous
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Citations

May 3, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maria Goretti M G Penido, Uri S Alon
Mar 8, 2014·BoneKEy Reports·Seiji Fukumoto
Jun 1, 2014·Bone·Despoina GkentziDionisios Chrysis
Jun 3, 2015·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Pramod R SomvanshiK V Venkatesh
Mar 27, 2015·Biotechnology Letters·Lata Sheo Bachan Upadhyay, Nishant Verma
May 11, 2016·International Journal of Environmental Research and Public Health·Karen Van den Bussche On Behalf Of The Dedipac Consortium
Aug 2, 2016·Chemical & Pharmaceutical Bulletin·Toshinori SuzukiYuki Koide
May 19, 2016·PloS One·Daniel Gomes da RochaCedric K W Tan
Apr 5, 2017·Calcified Tissue International·Ryan D Ross, D Rick Sumner
Apr 5, 2017·Hormone Research in Pædiatrics·Marta LempickiAgnès Linglart
Nov 23, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Louis L HuangLawrence P McMahon
Sep 21, 2016·World Journal of Nephrology·Cláudia RibeiroLucas José de Campos Machado
Feb 20, 2018·BioMed Research International·Maria Goretti Moreira Guimarães PenidoUri Saggie Alon
Sep 22, 2018·International Journal of Dermatology·Karen Sánchez-ArmendárizJudith Domínguez-Cherit
Sep 16, 2018·Nature Reviews. Endocrinology·Sampada Chande, Clemens Bergwitz
Mar 6, 2019·Public Health Nutrition·Melissa M MeloughOck K Chun
Jul 3, 2019·Alimentary Pharmacology & Therapeutics·Trond Espen DetlieJørgen Jahnsen
Apr 22, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Nurul Nadirah RazaliKaruppiah Thilakavathy
May 13, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Amish ChinoyRaja Padidela
Nov 16, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Erik A B HughesLiam M Grover
Aug 31, 2019·Journal of Clinical Pathology·Jenny Leung, Martin Crook
Jan 22, 2020·The Analyst·Aniruddha RayAydogan Ozcan
Aug 28, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tuyet Thi NguyenKyu-Sang Park
Mar 18, 2020·Journal of Animal Physiology and Animal Nutrition·Christian GerlingerPetra Wolf
Feb 6, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paula Suarez-BreguaJosep Rotllant
Feb 19, 2014·Current Opinion in Pediatrics·Michel Baum
Nov 27, 2019·Research in Sports Medicine·Bostjan JakseDorica Sajber
Jan 21, 2016·The Journal of Clinical Endocrinology and Metabolism·Gabriela Katharina MuschitzChristian Muschitz
Jun 1, 2013·Bone Research·Xianglan HuangWeibo Xia
Mar 17, 2018·Experimental and Therapeutic Medicine·Hai-Tao HouXiao-Hui Wang
Mar 23, 2018·International Journal of Molecular Sciences·Yun-Ho HwangSung-Tae Yee
Aug 30, 2018·International Journal of Molecular Sciences·Su-Jin KimSung-Tae Yee
Oct 18, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maria FusaroMario Cozzolino
Jul 28, 2020·Calcified Tissue International·Sanjay Kumar Bhadada, Sudhaker D Rao
Jul 14, 2017·Archives of Osteoporosis·Tiffany C YangHelen M Macdonald
Jun 14, 2017·Scientific Reports·Mara Heather O' BrienSumit Yadav

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