Phosphate Limitation Induces Drastic Physiological Changes, Virulence-Related Gene Expression, and Secondary Metabolite Production in Pseudovibrio sp. Strain FO-BEG1

Applied and Environmental Microbiology
Stefano RomanoVladimir Bondarev

Abstract

Phosphorus is a vital nutrient for living organisms and is obtained by bacteria primarily via phosphate uptake. However, phosphate is often scarcely accessible in nature, and there is evidence that in many areas of the ocean, its concentration limits bacterial growth. Surprisingly, the phosphate starvation response has been extensively investigated in different model organisms (e.g., Escherichia coli), but there is a dearth of studies on heterotrophic marine bacteria. In this work, we describe the response of Pseudovibrio sp. strain FO-BEG1, a metabolically versatile alphaproteobacterium and potential symbiont of marine sponges, to phosphate limitation. We compared the physiology, protein expression, and secondary metabolite production under phosphate-limited conditions to those under phosphate surplus conditions. We observed that phosphate limitation had a pleiotropic effect on the physiology of the strain, triggering cell elongation, the accumulation of polyhydroxyalkanoate, the degradation of polyphosphate, and the exchange of membrane lipids in favor of phosphorus-free lipids such as sulfoquinovosyl diacylglycerols. Many proteins involved in the uptake and degradation of phospho-organic compounds were upregulated, together ...Continue Reading

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Citations

Oct 16, 2019·Nature Microbiology·Rebecca AnsorgeJillian Petersen
Sep 5, 2020·Biofouling·Ingrid S M PinelJohannes S Vrouwenvelder
May 19, 2017·Evolutionary Applications·Hanna KinnulaLotta-Riina Sundberg
May 11, 2017·Frontiers in Microbiology·Punidan D JeyasinghJames B Cotner
Oct 11, 2019·International Journal of Environmental Research and Public Health·Qing WangLei Yu
Feb 18, 2018·Applied and Environmental Microbiology·Stefano Romano
Jul 26, 2018·Marine Drugs·Stefano RomanoAlan D W Dobson
Mar 7, 2021·Science·Darcy L McRose, Dianne K Newman
Mar 16, 2021·Microbes and Environments·Suzune ShindohSatoru Suzuki
Apr 15, 2021·Molecular Plant-microbe Interactions : MPMI
Jun 23, 2021·MSystems·Michael SweetRaquel Peixoto

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