PMID: 6401918Mar 1, 1983Paper

Phosphate replacement during treatment of diabetic ketosis. Effects on calcium and phosphorus homeostasis

American Journal of Diseases of Children
D J BeckerA L Drash

Abstract

Thirty-five patients with diabetic ketosis were given initial intravenous (IV) potassium replacement as phosphate (N = 13) or chloride (N = 13), or received no potassium replacement other than that contained in a normal diet (N = 9). All patients experienced a slight decrease in serum calcium level by 12 hours after the start of insulin therapy, but there was no statistically significant change in serum ionized calcium values. The phosphorus-supplemented group had significantly lower serum phosphorus concentrations at 24 and 36 hours when compared with patients receiving no IV hydration and excreted significantly more phosphorus during the first 12 hours of the study than either of the other two groups of patients. Our use of phosphorus supplements (4.7 to 28.5 mg/kg) did not cause abnormalities in calcium metabolism but did not prevent late hypophosphatemia.

Citations

Jan 23, 2004·Archives of Disease in Childhood·D B DungerUNKNOWN LWPES
Nov 1, 1985·The American Journal of Medicine·R KeblerP Cadnapaphornchai
May 27, 2008·Pediatric Clinics of North America·James P OrlowskiMariano R Fiallos
Aug 7, 2013·Emergency Medicine Clinics of North America·Laura Olivieri, Rose Chasm
Nov 23, 2005·Pediatric Clinics of North America·Nicole Glaser
Jul 3, 2004·Pediatric Emergency Care·Nicole Glaser, Nathan Kuppermann
Mar 8, 2007·Pediatric Diabetes·Joseph WolfsdorfUNKNOWN International Society for Pediatric and Adolescent Diabetes
Dec 1, 1990·Australian and New Zealand Journal of Medicine·P S HamblinJ R Stockigt
Sep 17, 2009·Pediatric Diabetes·Joseph WolfsdorfRagnar Hanas
Jun 1, 1989·Diabetes/metabolism Reviews·A E Kitabchi
Dec 4, 2010·Indian Journal of Pediatrics·Sindhu SivanandanRakesh Lodha
Oct 16, 1989·The Medical Journal of Australia·P S HamblinJ R Stockigt

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