Phosphate transport in pig proximal small intestines during postnatal development: lack of modulation by calcitriol

Endocrinology
B SchröderG Breves

Abstract

The role of calcitriol in the intestinal absorption of inorganic phosphate (Pi) during postnatal development was studied in newborn [<1 week postpartum (pp)], suckling (3-4 weeks pp), and weaned (>6 weeks pp) control piglets (con) and piglets suffering from inherited calcitriol deficiency (def). In addition, a number of def piglets were treated with vitamin D3 (def-D3). Regardless of age, plasma calcitriol concentrations in def piglets were unphysiologically low (16-21 pg/ml) and differed significantly from those in respective con animals (60-69 pg/ml) and vitamin D3-treated def piglets (50-56 pg/ml). However, newborn and suckling def piglets had normal Ca (approximately 3.0 mmol/liter) and Pi (approximately 2.8 mmol/liter) plasma levels. Def piglets became hypocalcemic (1.9 mmol/liter) and hypophosphatemic (1.9 mmol/liter) between 4-6 weeks pp. Treatment with vitamin D3 significantly increased plasma Ca (3.2 mmol/liter) and Pi (2.7 mmol/liter) levels in weaned def animals. Regardless of calcitriol status, net Pi flux rates (active Pi absorption, as determined with the in vitro Ussing-chamber technique) from the upper small intestines was maximal at birth [170-224 nmol/(cm2 x h)] and decreased by approximately 80% during the fi...Continue Reading

References

Jul 15, 1992·Biochemical and Biophysical Research Communications·L X ZhouA W Norman
Mar 1, 1992·The Journal of Nutrition·I Nemere
Feb 1, 1991·The Journal of Physiology·B SchröderJ Harmeyer
Jun 1, 1991·The Journal of Physiology·S P Shirazi-BeecheyE M Wright
Nov 1, 1989·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·U Lachenmaier-CurrleJ Harmeyer
Jan 1, 1989·Annual Review of Physiology·R K Buddington, J M Diamond
Jan 1, 1988·Comparative Biochemistry and Physiology. A, Comparative Physiology·M W Smith
Jan 1, 1988·Biology of the Neonate·U Lachenmaier-Currle, J Harmeyer
Jan 1, 1986·The Journal of Membrane Biology·H J Binder, H Murer
Jan 1, 1984·Comparative Biochemistry and Physiology. A, Comparative Physiology·M W SmithM A Peacock
Feb 1, 1980·Pediatric Research·G L Feldman, B Wolf
Mar 1, 1995·Journal of Cellular Biochemistry·R Kumar
Aug 1, 1993·The Proceedings of the Nutrition Society·B H Hirst
Apr 1, 1993·Calcified Tissue International·B SchröderJ Harmeyer
Aug 1, 1995·Canadian Journal of Physiology and Pharmacology·N Krishnamra, P Taweerathitam
Jun 1, 1996·The Biochemical Journal·S ChristakosW Yang
May 1, 1996·The Journal of Physiology·B SchröderG Breves
Jun 15, 1997·The Biochemical Journal·Y TaketaniE Takeda
Nov 15, 1997·Cancer·W RankinT J Martin
Jan 1, 1991·Nutrition Research Reviews·G Breves, B Schröder

❮ Previous
Next ❯

Citations

Oct 15, 2003·Journal of Virology·Christel Schwegmann-WesselsGeorg Herrler
Oct 13, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·R BuscheG Breves
Jun 12, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jens HerrmannGerhard Breves
Nov 29, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Anja CehakGerhard Breves
Dec 17, 2011·The British Journal of Nutrition·Alexandra S MuscherKorinna Huber
Feb 8, 2002·American Journal of Physiology. Cell Physiology·Hua XuFayez K Ghishan
Nov 11, 2014·Annual Review of Animal Biosciences·Jack OdleChad H Stahl
Oct 4, 2000·Physiological Reviews·J Pácha
Aug 25, 2018·Applied Microbiology and Biotechnology·Georgette KörferUlrich Schwaneberg
Aug 4, 1998·The American Journal of Physiology·B SchroederG Breves
Oct 12, 1999·The American Journal of Physiology·O HattenhauerJ Biber
Jun 30, 2019·Applied Microbiology and Biotechnology·Kevin R HerrmannUlrich Schwaneberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.