Phosphate wasting disorders in adults.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
G MarcucciM L Brandi

Abstract

A cause of hypophosphatemia is phosphate wasting disorders. Knowledge concerning mechanisms involved in phosphate wasting disorders has greatly increased in the last decade by the identification of phosphatonins, among them FGF-23. FGF-23 is a primarily bone derived factor decreasing renal tubular reabsorption of phosphate and the synthesis of calcitriol. Currently, pharmacological treatment of these disorders offers limited efficacy and is potentially associated to gastrointestinal, renal, and parathyroid complications; therefore, efforts have been directed toward newer pharmacological strategies that target the FGF-23 pathway. This review focuses on phosphate metabolism, its main regulators, and phosphate wasting disorders in adults, highlighting the main issues related to diagnosis and current and new potential treatments.

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Citations

Aug 31, 2019·Current Osteoporosis Reports·Smita JhaKelly Roszko
May 16, 2020·Calcified Tissue International·Gemma Marcucci, Maria Luisa Brandi
Aug 11, 2020·Calcified Tissue International·Salvatore Minisola, Maria Luisa Brandi
Jul 14, 2020·World Journal of Gastroenterology : WJG·Vanessa A ArecoMaría E Peralta López
May 1, 2020·Physiological Reviews·Nati HernandoEleanor Lederer
Jan 8, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Tiziana CarandiniAnna M Pietroboni
Nov 19, 2020·Journal of the Endocrine Society·Kathryn DahirJill H Simmons
Mar 6, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M JiménezP Florenzano
Feb 23, 2021·JBMR Plus·Neeharika NandamMaya Styner
Apr 12, 2021·Calcified Tissue International·Alejandro MarinPablo Florenzano
May 20, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S GianniniM L Brandi
Aug 6, 2019·Joint, Bone, Spine : Revue Du Rhumatisme·Alvin Lee DayKenneth G Saag
Sep 9, 2021·Aging Clinical and Experimental Research·René Rizzoli

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