Phosphatidic acid in membrane rearrangements

FEBS Letters
Mikhail A ZhukovskyCarmen Valente

Abstract

Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from -1 to -2 and this change stabilizes protein-lipid interactions. The biochemical properties of PA also allow interactions with lipids in several subcellular compartments. Based on this feature, PA is involved in the regulation and amplification of many cellular signalling pathways and functions, as well as in membrane rearrangements. Thereby, PA can influence membrane fusion and fission through four main mechanisms: it is a substrate for enzymes producing lipids (lysophosphatidic acid and diacylglycerol) that are involved in fission or fusion; it contributes to membrane rearrangements by generating negative membrane curvature; it interacts with proteins required for membrane fusion and fission; and it activates enzymes whose products are involved in membrane rearrangements. Here, we discuss the biophysical properties of PA in the context of the above four roles of PA in membrane fusion and fission.

References

Dec 20, 1979·Biochimica Et Biophysica Acta·P R Cullis, B de Kruijff
Jan 1, 1992·Chemistry and Physics of Lipids·R A DemelH Hauser
Jul 27, 1983·Biochimica Et Biophysica Acta·K HongD Papahadjopoulos
Feb 12, 1980·Biochemical and Biophysical Research Communications·M J Hope, P R Cullis
Jul 25, 1993·Biochimica Et Biophysica Acta·D H Butler, M G McNamee
Sep 9, 1997·Biochemistry·G GimplF Fahrenholz
May 23, 1998·The Journal of Biological Chemistry·W S DavidsonJ M George
Jul 11, 1998·The Journal of Biological Chemistry·A Siddhanta, D Shields
Oct 29, 1999·European Journal of Biochemistry·K Athenstaedt, G Daum
Apr 15, 2000·The Journal of Biological Chemistry·C LeeS G Rhee
Aug 1, 2000·The Journal of Biological Chemistry·E JoP E Fraser
Oct 19, 2000·The Journal of Cell Biology·E GroteP J Novick
Nov 25, 2000·Cellular and Molecular Life Sciences : CMLS·K BurgerF Fahrenholz
Feb 24, 2001·Traffic·J Zimmerberg
Feb 24, 2001·Traffic·K N Burger
Apr 20, 2001·Advanced Drug Delivery Reviews·I M Hafez, P R Cullis
Jun 13, 2001·Biochemical and Biophysical Research Communications·D M Harsh, R A Blackwood
Jul 4, 2001·Nature Reviews. Molecular Cell Biology·H SprongG van Meer
Nov 28, 2001·European Journal of Biochemistry·J M HolopainenI Järvelä
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y HumeauB Poulain
Jun 19, 2002·Biochimica Et Biophysica Acta·Daniela CordaChristopher P Berrie
Nov 2, 2002·The Journal of Biological Chemistry·Anirban SiddhantaDennis Shields
Feb 15, 2003·Biochimica Et Biophysica Acta·Paula J Booth
Jun 28, 2003·Biophysical Journal·Yonathan Kozlovsky, Michael M Kozlov

❮ Previous
Next ❯

Citations

Sep 10, 2019·FEBS Letters·Maria Antonietta De MatteisAlberto Luini
Jun 10, 2020·Brain : a Journal of Neurology·Ana CascalhoRose E Goodchild
May 13, 2020·The New Phytologist·Petra C BoevinkStephen C Whisson
Jul 1, 2020·Essays in Biochemistry·Sang-Chul Kim, Xuemin Wang
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Mikhail A ZhukovskyCarmen Valente
Jul 17, 2020·Frontiers in Cell and Developmental Biology·Yeojin Moon, Youngsoo Jun
Apr 12, 2020·International Journal of Molecular Sciences·Sandra BurattaCarla Emiliani
Sep 20, 2020·International Journal of Molecular Sciences·Fumio SakaneChiaki Murakami
Oct 16, 2020·Protein Science : a Publication of the Protein Society·Karolina Corin, James U Bowie
Jan 20, 2021·The Journal of Cell Biology·David J ThallerC Patrick Lusk
Aug 18, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Mathieu BorelSaida Mebarek
Feb 28, 2021·Cellular and Molecular Life Sciences : CMLS·Ana Rita CavacoAndreia Figueiredo
Dec 19, 2020·Chemistry and Physics of Lipids·Dipita Bhattacharyya, Anirban Bhunia
Mar 7, 2021·International Journal of Environmental Research and Public Health·Tiago MateusSandra Rebelo
Dec 15, 2020·Trends in Plant Science·Jingjing XingJinxing Lin
May 1, 2021·Pharmaceutics·Mariaevelina AlfieriAlfredo Ambrosone
Jun 21, 2021·International Journal of Biological Macromolecules·Emilio M Serrano-LópezSenena Corbalán-García
Aug 8, 2021·International Journal of Molecular Sciences·Rezlène BarguiMaryline Moulin
Sep 15, 2021·Journal of Proteome Research·Xiao X ZhangFranck Duong
Oct 3, 2021·Developmental Cell·Francisco S MesquitaF Gisou van der Goot
Nov 2, 2021·Medicinal Research Reviews·Prema K AgarwalaShobhna Kapoor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
H Kanoh
Acta biochimica Polonica
Jolanta ZegarlińskaAleksander Czogalla
Sheng li ke xue jin zhan [Progress in physiology]
N K Liu, C S Tang
© 2021 Meta ULC. All rights reserved