Phosphatidylcholine-associated aspirin accelerates healing of gastric ulcers in rats

Digestive Diseases and Sciences
A Kurinets, Lenard M Lichtenberger

Abstract

Based on our previous studies that aspirin (ASA) -induced gastric ulceration in rats can be significantly reduced if the drug is chemically associated with phosphatidylcholine (PC), we undertook the present study to compare gastric ulcer healing rates in rats administered either unmodified or PC-complexed ASA. Gastric ulcers were induced in anesthetized rats by briefly exposing the mucosal surface to 0.2 ml 60% acetic acid followed by randomization of the rats to study groups; daily intragastrically administered saline (control), ASA (36, 54 mg/kg), or ASA-PC complex. In contrast to the 65-70% reduction in ulcer size recorded in controls, ulcer healing was significantly retarded in rats administered unmodified ASA. Conversely, the size of the experimentally induced ulcers was less than control values in rats daily administered the PC-associated ASA, suggesting an acceleration in the rate of ulcer healing. Daily intragastric administration of ASA to rats over the study period also resulted in a significant decrease in surface hydrophobicity from control values as measured by contact angle analysis. However, surface hydrophobicity was partially restored in rats administered the PC-complexed ASA. Consistent with these findings, it...Continue Reading

Citations

Aug 5, 2005·Biological & Pharmaceutical Bulletin·Susumu Okabe, Kikuko Amagase
Jan 20, 2019·Scientific Reports·Marek KłobuckiCzesław Wawrzeńczyk
Jul 16, 1999·The American Journal of Gastroenterology·B S AnandL M Lichtenberger
Oct 13, 2006·Current Opinion in Gastroenterology·B Cryer
Jan 10, 2012·Lipids in Health and Disease·Daniela KüllenbergUlrich Massing
Oct 13, 2006·Current Opinion in Gastroenterology·B Cryer
Dec 23, 2016·Medicinal Research Reviews·Catarina Pereira-LeiteSalette Reis
Dec 15, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A BhattacharyaS K Bhattacharya

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