Phosphatidylcholine biosynthesis and its significance in bacteria interacting with eukaryotic cells

European Journal of Cell Biology
Meriyem AktasFranz Narberhaus

Abstract

Phosphatidylcholine (PC), a typical eukaryotic membrane phospholipid, is present in only about 10% of all bacterial species, in particular in bacteria interacting with eukaryotes. A number of studies revealed that PC plays a fundamental role in symbiotic and pathogenic microbe-host interactions. Agrobacterium tumefaciens mutants lacking PC are unable to elicit plant tumors. The human pathogens Brucella abortus and Legionella pneumophila require PC for full virulence. The plant symbionts Bradyrhizobium japonicum and Sinorhizobium meliloti depend on wild-type levels of PC to establish an efficient root nodule symbiosis. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (Pcs) pathway. The methylation pathway involves a three-step methylation of phosphatidylethanolamine by at least one phospholipid N-methyltransferase to yield phosphatidylcholine. In the Pcs pathway, choline is condensed directly with CDP-diacylglycerol to form PC. This review focuses on the biosynthetic pathways and the significance of PC in bacteria with an emphasis on plant-microbe interactions.

References

Jan 1, 1990·Progress in Lipid Research·C Kent
Jul 1, 1984·Journal of Bacteriology·M S Hindahl, B H Iglewski
Jan 1, 1981·Methods in Enzymology·D E Vance, W J Schneider
Jan 1, 1994·Annual Review of Nutrition·S H Zeisel, J K Blusztajn
Apr 14, 1994·Biochimica Et Biophysica Acta·J H Exton
Nov 25, 1997·Biochimica Et Biophysica Acta·D E VanceZ Cui
Jul 3, 1999·The Journal of Biological Chemistry·K E de RudderO Geiger
Dec 22, 1999·The Journal of Biological Chemistry·M Bogdanov, W Dowhan
Jun 20, 2000·The Journal of Biological Chemistry·C SohlenkampO Geiger
Sep 22, 2001·Journal of Biotechnology·I M López-Lara, O Geiger
Aug 10, 2002·Journal of Bacteriology·Paula J WildermanMichael L Vasil
Jan 28, 2003·Progress in Lipid Research·Christian SohlenkampOtto Geiger
Jul 5, 2003·The Journal of Biological Chemistry·David J ShieldsDennis E Vance
Jul 10, 2003·Molecular Plant-microbe Interactions : MPMI·Isabel M López-LaraOtto Geiger
Oct 7, 2003·Annual Review of Microbiology·John E Cronan
Dec 10, 2003·Microbiology·Fernando Martínez-MoralesOtto Geiger
Dec 14, 2004·Nature Biotechnology·Jeong-Sun SeoHyen Sam Kang
Feb 18, 2006·Journal of Bacteriology·Diego J ComerciRodolfo A Ugalde
Oct 3, 2006·Molecular Microbiology·Mirja WesselFranz Narberhaus
Sep 21, 2007·The Journal of Biological Chemistry·Dennis E VanceRené L Jacobs
Feb 12, 2008·Nature Reviews. Microbiology·Yong-Mei Zhang, Charles O Rock
May 1, 2008·Molecular Genetics and Genomics : MGG·Stephanie HackerFranz Narberhaus
Aug 26, 2009·Progress in Lipid Research·Otto GeigerChristian Sohlenkamp
Dec 25, 2009·FEMS Microbiology Letters·Daniela B MedeotIsabel M López-Lara
Mar 13, 2010·The Journal of Biological Chemistry·Adelin GustotCédric Govaerts

❮ Previous
Next ❯

Citations

Oct 11, 2011·Lipids·Frederic D MüllerMichael W Linscheid
May 24, 2011·Journal of Bacteriology·Meriyem AktasFranz Narberhaus
Nov 20, 2012·Journal of Bacteriology·Claudia K HerrmannDiego J Comerci
Aug 2, 2011·Journal of Bacteriology·Meriyem AktasFranz Narberhaus
Sep 8, 2012·Investigative Ophthalmology & Visual Science·Ashley M CraneSanjoy K Bhattacharya
Jan 10, 2016·Biochimica Et Biophysica Acta·Rosemary B Cornell
Jun 25, 2013·Maturitas·Antonio González-SarríasJuan Carlos Espín
Jun 9, 2015·Physiological and Biochemical Zoology : PBZ·Evan L PannkukThomas S Risch
Dec 18, 2013·Molecular Microbiology·Roman MoserFranz Narberhaus
Apr 9, 2014·Molecular Microbiology·Roman MoserFranz Narberhaus
Nov 18, 2014·Molecular Microbiology·Linna DanneFranz Narberhaus
Aug 28, 2012·Biochimica Et Biophysica Acta·Otto GeigerChristian Sohlenkamp
Apr 12, 2014·Frontiers in Plant Science·Meriyem AktasFranz Narberhaus
Dec 4, 2014·PloS One·Julie M DaviesMaria T Abreu
May 27, 2016·Molecular Biology of the Cell·Charli D BakerVishal M Gohil
Sep 15, 2016·Scientific Reports·Silvia TurroniMarco Candela
Apr 21, 2017·Critical Reviews in Biotechnology·Bruna Soares FernandesJosé Geraldo da Cruz Pradella
Jun 17, 2014·The FEBS Journal·Meriyem AktasFranz Narberhaus
Mar 20, 2012·Nature Materials·Xifei YuDonald E Brooks
Jan 20, 2019·Proceedings of the National Academy of Sciences of the United States of America·Laura Gomez-ValeroCarmen Buchrieser
Sep 11, 2019·Journal of Bacteriology·Luke R JoyceKelli L Palmer
Feb 12, 2021·Microbiology and Molecular Biology Reviews : MMBR·R Martin RoopDaniel W Martin
Mar 12, 2021·Fish Physiology and Biochemistry·Jianshuang LiXin Qi
Mar 27, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Georgios VasilopoulosFranz Narberhaus
Jul 22, 2021·Applied and Environmental Microbiology·Julia KleetzFranz Narberhaus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brucellosis (ASM)

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.

Brucellosis

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.