Phosphatidylcholine Membrane Fusion Is pH-Dependent

International Journal of Molecular Sciences
Sergey A AkimovOleg V Batishchev

Abstract

Membrane fusion mediates multiple vital processes in cell life. Specialized proteins mediate the fusion process, and a substantial part of their energy is used for topological rearrangement of the membrane lipid matrix. Therefore, the elastic parameters of lipid bilayers are of crucial importance for fusion processes and for determination of the energy barriers that have to be crossed for the process to take place. In the case of fusion of enveloped viruses (e.g., influenza) with endosomal membrane, the interacting membranes are in an acidic environment, which can affect the membrane's mechanical properties. This factor is often neglected in the analysis of virus-induced membrane fusion. In the present work, we demonstrate that even for membranes composed of zwitterionic lipids, changes of the environmental pH in the physiologically relevant range of 4.0 to 7.5 can affect the rate of the membrane fusion notably. Using a continual model, we demonstrated that the key factor defining the height of the energy barrier is the spontaneous curvature of the lipid monolayer. Changes of this parameter are likely to be caused by rearrangements of the polar part of lipid molecules in response to changes of the pH of the aqueous solution bat...Continue Reading

References

Aug 1, 1978·Biophysical Journal·J F Nagle, D A Wilkinson
Oct 5, 1987·Biochimica Et Biophysica Acta·L V ChernomordikY A Chizmadzhev
Dec 21, 1987·Journal of Theoretical Biology·S L LeikinY A Chizmadzhev
Jan 1, 1983·Annual Review of Biochemistry·R A Lamb, P W Choppin
Jun 27, 2000·Biophysical Journal·W RawiczE Evans
Jun 29, 2000·Annual Review of Biochemistry·R Jahn, T C Südhof
Aug 31, 2000·Annual Review of Biochemistry·J J Skehel, D C Wiley
Oct 24, 2000·Current Opinion in Structural Biology·B R LentzK Evans
Jun 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·P I KuzminF S Cohen
Mar 7, 2002·Developmental Cell·William A MohlerBenjamin Podbilewicz
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Melike LakadamyaliXiaowei Zhuang
Oct 7, 2003·Annual Review of Biochemistry·Leonid V Chernomordik, Michael M Kozlov
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Paul L McNeil, Richard A Steinhardt
Aug 17, 2006·Nature Reviews. Molecular Cell Biology·Reinhard Jahn, Richard H Scheller
Oct 18, 2006·The Journal of Cell Biology·Leonid V ChernomordikMichael M Kozlov
Mar 17, 2007·Annual Review of Biochemistry·Suzanne HoppinsJodi Nunnari
Mar 31, 2007·FEBS Letters·Elizabeth H ChenAgnès Vignery
May 5, 2007·Science·Sascha MartensHarvey T McMahon
Jul 20, 2007·Nature Reviews. Molecular Cell Biology·J Paul LuzioNicholas A Bright
Jan 16, 2008·Developmental Cell·Amir SapirLeonid V Chernomordik
Jul 4, 2008·Nature Structural & Molecular Biology·Leonid V Chernomordik, Michael M Kozlov
Jul 4, 2008·Nature Structural & Molecular Biology·Meyer B Jackson, Edwin R Chapman
Jul 12, 2008·Nature Structural & Molecular Biology·William Wickner, Randy Schekman
Jul 12, 2008·Nature Structural & Molecular Biology·Josep Rizo, Christian Rosenmund
Mar 29, 2014·Soft Matter·Benjamin KollmitzerGeorg Pabst
Apr 14, 2015·Virology·Stephen C Harrison
Jul 15, 2015·Scientific Reports·Lando L G SchwenenClaudia Steinem
Oct 8, 2016·Physical Review Letters·A J SodtR W Pastor
Dec 7, 2017·International Journal of Molecular Sciences·Rodion J MolotkovskySergey A Akimov
Mar 2, 2018·Annual Review of Biophysics·Sander BoonstraAntoine M van Oijen

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Citations

Jun 4, 2020·International Journal of Molecular Sciences·Sergey A AkimovOleg V Batishchev
Aug 6, 2020·International Journal of Molecular Sciences·Sergey A AkimovOleg V Batishchev
Jul 10, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Cassidy C DolstraDarryl Y Sasaki

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