PMID: 172134Nov 21, 1975Paper

Phosphatidylglycerol in lung surfactant. II. Subcellular distribution and mechanism of biosynthesis in vitro

Biochimica Et Biophysica Acta
M Hallman, L Gluck


Lamellar inclusion bodies, apparent precursors for alveolar surfactant lining, have remarkably similar phospholipid composition to surfactant from alveolar lavage, but distinctly different from other fractions studied: mitochondria, microsomal fraction containing endoplasmic reticulum membranes, plasma membranes and nuclei. Surfactant contained (as % of total phospholipid phosphate): 75.5-77.0% lecithin, 11.0-11.2% phosphatidylglycerol, 4.2-4.6% phosphatidylethanolamine, 3.0-3.2% phosphatidylinositol, 1.5-1.7% bis-(monoacylglycerol) phosphate, 1.2-1.9% phosphatidylserine, and 0.7-1.5% sphingomyelin. Fatty acids of phosphatidylglycerol from lamellar bodies were similar to those from microsomes but different from those in mitochondria. Lung homogenate in continuous sucrose density gradient displayed two major activity peaks of phosphatidylglycerol synthesis: the heavier from mitochondria; the lighter from endoplasmic reticulum. Studies on mechanism of phosphatidylglycerol synthesis in vitro revealed (in these two fractions) CDP-diglyceride and sn-glycerol phosphate precursors to phosphatidylglycerol phosphate, that hydrolysed to phosphatidylglycerol. In microsomes disaturated CDP-diglycerides were 1.6-1.9 times more active substr...Continue Reading


Jan 1, 1970·Annual Review of Biochemistry·W J Lennarz
Feb 21, 1972·Biochimica Et Biophysica Acta·B A Page-Roberts
Sep 1, 1972·The Journal of Clinical Investigation·R J MasonM Vaughan
Nov 1, 1972·The Tohoku Journal of Experimental Medicine·N Toshima, T Akino
Jul 26, 1974·Biochimica Et Biophysica Acta·S A RooneyE K Motoyama
Sep 9, 1974·Biochemical and Biophysical Research Communications·M Hallman, L Gluck
Apr 18, 1972·Biochimica Et Biophysica Acta·M O Marshall, M Kates
Mar 23, 1972·Biochimica Et Biophysica Acta·K Y HostetlerL L van Deenen
Sep 1, 1974·American Journal of Obstetrics and Gynecology·L GluckW N Keidel
Apr 1, 1973·The American Journal of Physiology·R J KingJ A Clements
Jun 8, 1971·Biochimica Et Biophysica Acta·K Y HostetlerL L Van Deenen
Jun 9, 1972·Biochemical and Biophysical Research Communications·N Z StanacevZ Domazet
Jul 1, 1972·Chemistry and Physics of Lipids·R C PflegerJ Waide
Mar 19, 1971·Biochemical and Biophysical Research Communications·J B Davidson, N Z Stanacev
Aug 1, 1956·Experimental Cell Research·J CHAUVEAUC ROUILLER
Feb 18, 1958·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R E PATTLE
May 1, 1961·Journal of Applied Physiology·J A CLEMENTSI GRIBETZ
Oct 1, 1960·The Journal of Biophysical and Biochemical Cytology·D M NEVILLE
Jun 1, 1960·Archives of Biochemistry and Biophysics·E H STRICKLAND, A A BENSON
Feb 26, 1962·Biochimica Et Biophysica Acta·J H VEERKAMPL van DEENEN
Feb 1, 1965·The Journal of Pediatrics·F H ADAMSA SCUDDER
Apr 1, 1965·Journal of the American Oil Chemists' Society·O RENKONEN
Dec 31, 1949·Nature·C S HANES, F A ISHERWOOD
Dec 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S P Sorokin
Jan 1, 1967·Lipids·M L Das, G Rouser

❮ Previous
Next ❯


Mar 1, 1986·Biulleten' eksperimental'noĭ biologii i meditsiny·P A Kazarian, K G Karagezian
Jan 1, 1985·Lipids·A Q KhanS K Das
Jan 1, 1981·Lung·R H PerelmanP M Farrell
Jan 1, 1987·The International Journal of Biochemistry·M N Diez-BlancoM Llanillo
Apr 1, 1983·Respiration Physiology·T E Nicholas, H A Barr
Jan 1, 1985·Molecular Aspects of Medicine·J L Harwood, R J Richards
May 23, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·C B Daniels, S Orgeig
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J Benson
Oct 1, 1976·Thorax·J GlosterP Harris
Apr 1, 1984·Environmental Health Perspectives·G George, G E Hook
Apr 1, 1984·Environmental Health Perspectives·Z Hruban
May 27, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ana Paula Avritscher BeckAntonio Fernandes Moron
Aug 1, 1978·Experimental and Molecular Pathology·G D StonerM C Troxell
Aug 1, 2006·Respiratory Physiology & Neurobiology·Natalie J FootChristopher B Daniels
Jun 21, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Natalie J MillerSandra Orgeig
Feb 27, 1980·Biochemical and Biophysical Research Communications·M Hallman, B L Epstein
Nov 15, 1980·American Journal of Obstetrics and Gynecology·H T StrassnerL D Platt
Feb 1, 1982·Experimental Lung Research·M PostL M van Golde
Apr 1, 1983·Experimental Lung Research·J W SpaldingG E Hook
Aug 1, 1997·The Annals of Thoracic Surgery·B R WilcoxR H Anderson
Sep 1, 1980·The Anatomical Record·K R Hitchcock
Apr 1, 1983·Clinical Physiology·B Robertson
Aug 19, 2017·Critical Reviews in Food Science and Nutrition·Abdelmoneim H AliXingguo Wang
Oct 19, 2005·The Journal of Biological Chemistry·Marwan AlfalahHassan Y Naim
Feb 3, 2007·The Journal of Biological Chemistry·Nobuhiro BanNobuya Inagaki
Aug 1, 1987·The American Review of Respiratory Disease·J R Wright, J A Clements
Sep 1, 1981·Critical Reviews in Toxicology·T Akino, K Ohno
Jan 20, 2017·Journal of Chemical Biology·Samuel Furse
Apr 1, 1984·Environmental Health Perspectives·S A Rooney
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Ruijiang ZhuoYuru Deng

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.