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Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production

Cellular Microbiology

Sep 9, 2011

Eike R HrinciusChristina Ehrhardt

Abstract

The phosphatidylinositol-3-kinase (PI3K) was identified to be activated upon influenza A virus (IAV) infection. An early and transient induction of PI3K signalling is caused by viral attachment to cells and promotes virus entry. In later phases of infection the kinase is activated by th...read more

Mentioned in this Paper

VTRNA1-1 gene
TRIM25 gene
PIK3CA protein, human
Genes, Reporter
Influenza
Interferon Regulatory Factor 3
Interferon Type I
Virus Internalization
IFIH1 gene
DDX58 gene
1
59
Paper Details
References
  • References34
  • Citations30
1234

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Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production

Cellular Microbiology

Sep 9, 2011

Eike R HrinciusChristina Ehrhardt

PMID: 21899695

DOI: 10.1111/j.1462-5822.2011.01680.x

Abstract

The phosphatidylinositol-3-kinase (PI3K) was identified to be activated upon influenza A virus (IAV) infection. An early and transient induction of PI3K signalling is caused by viral attachment to cells and promotes virus entry. In later phases of infection the kinase is activated by th...read more

Mentioned in this Paper

VTRNA1-1 gene
TRIM25 gene
PIK3CA protein, human
Genes, Reporter
Influenza
Interferon Regulatory Factor 3
Interferon Type I
Virus Internalization
IFIH1 gene
DDX58 gene
1
59

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References34
  • Citations30
1234
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