PMID: 6402024Jan 7, 1983Paper

Phosphatidylinositol and phosphatidic acid metabolism in rat pancreatic islets in response to neurotransmitter and hormonal stimuli

Biochimica Et Biophysica Acta
L Best, W J Malaisse

Abstract

Carbamylcholine produced a concentration-dependent stimulation of labelling of phosphatidylinositol and phosphatidic acid in rat islets of Langerhans following preincubation with 32PO43(-). The time course of these effects suggested that the initial action of carbamylcholine was to stimulate phosphatidic acid production, presumably by causing hydrolysis of phosphatidylinositol. This conclusion was substantiated by experiments in which islet phospholipids were pre-labelled with [3H]arachidonic acid. Under these conditions, carbamylcholine caused a loss of radioactivity from phosphatidylinositol, together with an increase in labelling of phosphatidic acid. The effects of carbamylcholine on islet phospholipid labelling were not dependent upon the presence of added Ca2+, but were abolished by EDTA and by atropine. An apparent stimulation of phosphatidylinositol and phosphatidic acid metabolism was also induced by cholecystokinin-pancreozymin, whereas glucagon, arginine, glibenclamide and thyrotropin had no significant effect. The data suggest that enhanced activity of the so-called phosphatidylinositol cycle may be an important event in regulating secretory activity of islets in response to certain neurotransmitter and hormonal sti...Continue Reading

References

Mar 25, 1975·Biochimica Et Biophysica Acta·R H Michell
Apr 18, 1975·Biochimica Et Biophysica Acta·G Fex, A Lernmark
Sep 1, 1972·The Proceedings of the Nutrition Society·W J Malaisse
Jan 28, 1982·Nature·J N Hawthorne

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Citations

Oct 15, 1984·Experientia·L BestW J Malaisse
Feb 4, 1990·Regulatory Peptides·G T SchuppinD J Fletcher
Jul 1, 1991·Acta Physiologica Scandinavica·S Karlsson, B Ahrén
Mar 1, 1984·The Journal of Clinical Investigation·S Kadowaki, A W Norman
Jan 31, 1992·Biochemical and Biophysical Research Communications·J WangJ C Brown
Feb 1, 1986·Archives of Biochemistry and Biophysics·M E Dunlop, W J Malaisse
Mar 1, 1986·Metabolism: Clinical and Experimental·E Vara, J Tamarit-Rodriguez
Jan 1, 1989·Diabetes Research and Clinical Practice·Y OkabayashiS Baba
Oct 14, 1983·Biochemical and Biophysical Research Communications·L Best, W J Malaisse
Jul 1, 1985·Cell Biochemistry and Function·P C MathiasW J Malaisse
May 15, 1985·European Journal of Biochemistry·W J MalaisseA Sener
Sep 1, 1984·The Journal of Allergy and Clinical Immunology·S A MetzR P Robertson
Jul 1, 1984·Biochemical Pharmacology·L BestW J Malaisse
Apr 30, 1992·Biochemical and Biophysical Research Communications·T FridolfB Ahrén
Oct 1, 1985·Biochemical Pharmacology·P C MathiasW J Malaisse
Jul 1, 1991·Molecular and Cellular Endocrinology·C J HedeskovK Capito

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