PMID: 3214465Aug 1, 1988Paper

Phosphatidylinositol (PI) and PI-associated arachidonate are elevated in platelet total membranes of type IIa hypercholesterolemic subjects

Atherosclerosis
C MosconiC Galli

Abstract

The lipid composition (phospholipid distribution and fatty acid patterns of individual glycerophospholipids) and levels of lipid components (cholesterol, total and individual phospholipid classes, arachidonic acid) have been determined in total membranes of platelets from type IIa hypercholesterolemic (HC) and control (C) subjects. Levels of cholesterol and total phospholipid, relative to the protein content, were about 80% and 60% higher respectively in platelet total membranes from HC subjects. Small differences between the two groups of samples were observed for the phospholipid distribution and the fatty acid patterns. Concentrations of individual phospholipid classes, were on the average 60% higher in HC than in C platelet membranes, with an even greater difference for phosphatidylinositol (PI) and sphingomyelin. Levels of arachidonic acid, relative to the protein content, were also 60-80% higher in membranes from HC platelet with a more than 100% increase in PI. The higher levels of the eicosanoid precursor fatty acid in phospholipids and especially in PI, which is considered a donor pool for eicosanoid synthesis, may be a contributing factor for the greater thromboxane formation and enhanced aggregation, upon stimulation...Continue Reading

References

Jan 1, 1979·Lancet·E TremoliC Galli
Mar 1, 1975·The Journal of Clinical Investigation·S J ShattilR A Cooper
Feb 21, 1974·The New England Journal of Medicine·A C CarvalhoR S Lees
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Jan 17, 1984·Biochemistry·M Steiner, E F Lüscher
Oct 1, 1984·European Journal of Clinical Investigation·E TremoliC R Sirtori
Jan 1, 1981·Progress in Lipid Research·D G Cornwell, R V Panganamala
Jan 3, 1980·The New England Journal of Medicine·M J StuartJ G White

❮ Previous
Next ❯

Citations

Dec 31, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·N Chetty, N H Naran
Jan 1, 1990·Thrombosis Research. Supplement·E TremoliR Paoletti
Mar 26, 2003·Journal of Cardiovascular Pharmacology and Therapeutics·Kailash Prasad, Paul Lee
Apr 14, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·I Anita JagroopDimitri P Mikhailidis
Jun 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·K H Le Quan SangM A Devynck
Nov 14, 1998·The American Journal of Physiology·P Dobner, B Engelmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.