Phosphatidylserine targeting for diagnosis and treatment of human diseases

Apoptosis : an International Journal on Programmed Cell Death
Kristof Schutters, Chris P M Reutelingsperger

Abstract

Cells are able to execute apoptosis by activating series of specific biochemical reactions. One of the most prominent characteristics of cell death is the externalization of phosphatidylserine (PS), which in healthy cells resides predominantly in the inner leaflet of the plasma membrane. These features have made PS-externalization a well-explored phenomenon to image cell death for diagnostic purposes. In addition, it was demonstrated that under certain conditions viable cells express PS at their surface such as endothelial cells of tumor blood vessels, stressed tumor cells and hypoxic cardiomyocytes. Hence, PS has become a potential target for therapeutic strategies aiming at Targeted Drug Delivery. In this review we highlight the biomarker PS and various PS-binding compounds that have been employed to target PS for diagnostic purposes. We emphasize the 35 kD human protein annexin A5, that has been developed as a Molecular Imaging agent to measure cell death in vitro, and non-invasively in vivo in animal models and in patients with cardiovascular diseases and cancer. Recently focus has shifted from diagnostic towards therapeutic applications employing annexin A5 in strategies to deliver drugs to cells that express PS at their s...Continue Reading

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Related Concepts

Molecular Imaging
Tumor Cells, Uncertain Whether Benign or Malignant
Annexin A5
Phosphatidylserines
Postmortem Diagnosis
Blood Vessel
ANXA5 gene
Plasma Protein Binding Capacity
Cardiovascular Diseases
phosphatidylserine

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis