Phosphine-catalyzed regiodivergent annulations of γ-substituted allenoates with conjugated dienes

Chemical Communications : Chem Comm
Zhenjie GanZheng Duan

Abstract

A phosphine catalyzed regiodivergent annulation of γ-substituted allenoates with conjugated dienes is reported, and highly functionalized cyclohexenes or cyclopentenes were obtained in high yields and regioselectivities. This transformation takes advantage of mild conditions, wide substrate scope and significant functional group tolerance. The high regioselectivity can be achieved by tuning the nucleophilicity of the phosphine catalyst.

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Citations

Dec 19, 2019·Chemical Communications : Chem Comm·Er-Qing Li, You Huang
Jun 1, 2021·ACS Central Science·Changmin XieOhyun Kwon
Jun 27, 2020·The Journal of Organic Chemistry·Sebastián Gallardo-FuentesIsrael Fernández

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