Phospho-p38 MAPK expression in COPD patients and asthmatics and in challenged bronchial epithelium

Respiration; International Review of Thoracic Diseases
Davide ValleseA Di Stefano

Abstract

The role of mitogen-activated protein kinases (MAPK) in regulating the inflammatory response in the airways of patients with chronic obstructive pulmonary disease (COPD) and asthmatic patients is unclear. To investigate the expression of activated MAPK in lungs of COPD patients and in bronchial biopsies of asthmatic patients and to study MAPK expression in bronchial epithelial cells in response to oxidative and inflammatory stimuli. Immunohistochemical expression of phospho (p)-p38 MAPK, p-JNK1 and p-ERK1/2 was measured in bronchial mucosa in patients with mild/moderate (n = 17), severe/very severe (n = 16) stable COPD, control smokers (n = 16), control non-smokers (n = 9), in mild asthma (n = 9) and in peripheral airways from COPD patients (n = 15) and control smokers (n = 15). Interleukin (IL)-8 and MAPK mRNA was measured in stimulated 16HBE cells. No significant differences in p-p38 MAPK, p-JNK or p-ERK1/2 expression were seen in bronchial biopsies and peripheral airways between COPD and control subjects. Asthmatics showed increased submucosal p-p38 MAPK expression compared to COPD patients (p < 0.003) and control non-smokers (p < 0.05). Hydrogen peroxide (H₂O₂), cytomix (tumour necrosis factor-α + IL-1β + interferon-γ) and ...Continue Reading

Citations

Apr 20, 2017·Science Signaling·Kate SengerAli A Zarrin
May 26, 2017·The European Respiratory Journal·Antonino Di StefanoBruno Balbi
Dec 7, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Katherine J BainesPeter G Gibson
Aug 25, 2020·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Antonino Di StefanoMaria Graziella Catalano

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