Phosphocholine-containing glycoglycerolipids (GGPL-I and GGPL-III) are species-specific major immunodeterminants of Mycoplasma fermentans

Biochemical and Biophysical Research Communications
K MatsudaN Yamamoto

Abstract

Mycoplasma fermentans has unique glycoglycerophospholipids (GGPLs: GGPL-I and GGPL-III). Previously, the structure of these lipids was determined as phosphocholine-6'-alpha-glucopyranosyl-(1'-3)-1, 2-diacyl-glycerol (GGPL-I) and 1"-phosphocholine-2"-aminodihydroxypropane-3"-phospho-6'-alph++ + a- glucopyranosyl-(1'-3)-1, 2-diacyl-glycerol (GGPL-III). Thin-layer chromatography (TLC) immunostaining showed that the GGPLs were main lipid-antigens of the M. fermentans species. Anti-M. fermentans serum stained mainly the GGPLs, but the other anti-mycoplasma sera (anti-M. arginini, anti-M. hyorhinis, anti-M. pneumonia, anti-M. primatum, and anti-Acholeplasma laidlawii, anti-M. hominis, anti-M. orale, and M. salivarium) stained neither GGPL-I nor GGPL-III. The TLC analysis of glycolipids and phospholipids of various human related mycoplasmas showed clearly that GGPLs are specifically expressed in M. fermentans species. GGPL-I and GGPL-III ranged from 1.6 to 28% and from an undetectable level to 35% of total phospholipids, respectively. Although there was heterogeneity among the amounts of GGPL-I or GGPL-III of M. fermentans strains, all of the M. fermentans strains had GGPL-I and/or GGPL-III. These observations showed that GGPL structu...Continue Reading

References

Sep 1, 1991·Infection and Immunity·C T StädtlanderG H Cassell
Jun 1, 1987·Microbiological Reviews·C R Woese
Nov 1, 1989·The American Journal of Tropical Medicine and Hygiene·S C LoR Y Wang
Feb 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·J E Volanakis, M H Kaplan
Mar 20, 1993·Lancet·C BebearP Morlat
Aug 1, 1993·Infection and Immunity·K S WiseS C Lo
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

Jul 19, 2003·European Journal of Biochemistry·Klaus BrandenburgUlrich Seydel
Feb 6, 2010·The Journal of Veterinary Medical Science·Masatoshi FujiharaRyô Harasawa
Oct 6, 2000·Microbiology and Immunology·K MatsudaN Yamamoto
May 9, 2012·Beilstein Journal of Organic Chemistry·Yoshihiro NishidaKazuhiro Matsuda
Sep 30, 2000·European Journal of Biochemistry·F WagnerU Zähringer
Jul 11, 2002·Microbes and Infection·Shlomo Rottem
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·S RazinY Naot
May 8, 2007·Systematic and Applied Microbiology·Hanna Lucia WorliczekHans-Jürgen Busse
Mar 1, 2008·Biochemical and Biophysical Research Communications·Yutaka KawahitoKazuhiro Matsuda
Mar 17, 2010·Journal of Bioscience and Bioengineering·Noriko IshidaKozo Asano

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