Phosphocholine epitopes on helminth and protozoal parasites and their presence in the circulation of infected human patients.

Transactions of the Royal Society of Tropical Medicine and Hygiene
R B Lal, E A Ottesen

Abstract

Antigens containing phosphocholine (PC) circulate in the blood during chronic filarial infection. Because of the wide occurrence of such PC epitopes, we examined their specificity by evaluating 10 common parasites of humans for the presence of PC epitopes, and sera from patients infected with these parasites for circulating antigens containing PC. Immunoblot analysis of extracts from various parasites using an anti-PC monoclonal antibody (CA101) demonstrated the presence of PC epitopes on the protozoa Leishmania major and Trypanosoma cruzi, and on the helminths Schistosoma mansoni and Strongyloides stercoralis, in addition to those previously described on Trichinella spiralis, Onchocerca volvulus and Brugia malayi. They were not detected on the protozoa Entamoeba histolytica, Giardia lamblia or Plasmodium falciparum. Sera from 163 individuals with single protozoan or helminth infections were assayed for PC-bearing circulating antigens in a two-site immunoassay; such antigens were found in almost all patients infected with Wuchereria bancrofti; in half of those infected with S. stercoralis; and in 7-15% of those with S. mansoni, T. cruzi or L. donovani; none was detected in those with Trichinella, hookworm, Echinococcus, malaria...Continue Reading

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Citations

Jul 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·A M PoldermanJ P Rotmans
Mar 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·D J ConwayA E Bianco
Mar 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·A J TerhellM Yazdanbakhsh
Apr 22, 1999·Immunology Today·W Harnett, M M Harnett
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Dec 12, 2012·Infection and Immunity·Sarah E Clark, Jeffrey N Weiser
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·John F CipolloCarlos B Hirschberg
Jul 30, 1999·Experimental Parasitology·A HeiseH Zahner
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Dec 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thomas TimmGünter Lochnit
Aug 19, 2005·European Journal of Mass Spectrometry·Julia GrabitzkiGünter Lochnit
Dec 29, 2000·The Journal of Parasitology·G G NuñezS M Venturiello
Apr 6, 2016·The Journal of Biological Chemistry·Umul Kulthum AhmedJohn G Raynes
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C L KingJ W Kazura

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