Phosphocreatine content and intracellular pH of calf muscle measured by phosphorus NMR spectroscopy in occlusive arterial disease of the legs

European Journal of Clinical Investigation
U KellerJ Seelig

Abstract

Energy metabolism of calf muscle was assessed non-invasively by phosphorus (31P) NMR spectroscopy in eleven patients with symptomatic arterial occlusion and in seven matched controls. Phosphocreatine (PCr) content and pH values decreased during non-ischaemic foot exercise to lower values in severely afflicted patients but in all patients, as a group, they were not significantly decreased compared to controls. In contrast, recovery from ischaemic exercise (arterial occlusion by a tourniquet) demonstrated significant differences between patients and controls. Intracellular pH and PCr recovered more slowly in patients than in controls; PCr recovery proceeded exponentially with a recovery half-time of 203 +/- 74 s in patients compared to 36.7 +/- 5.5 s in controls (P less than 0.02). Phosphocreatine (PCr) recovery after ischaemic exercise correlated significantly with the degree of arterial stenoses as assessed by Doppler ultrasound (r = 0.739, P = 0.019) and by angiography (r = 0.885, P = 0.005), suggesting that the degree of large vessel stenoses limits the postischaemic increase in mitochondrial oxidative phosphorylation. Reactive blood flow after ischaemia failed to correlate with PCr recovery or with the degree of arterial ste...Continue Reading

References

Nov 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R C HarrisE Hultman
Nov 30, 1976·European Journal of Clinical Investigation·A C BylundT Scherstén
Dec 28, 1976·Pflügers Archiv : European journal of physiology·R C HarrisK Sahlin
Aug 1, 1972·European Journal of Clinical Investigation·J HolmT Scherstén
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·B PERNOW, S Zetterquist
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B ChanceR Warnell
Sep 1, 1984·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D L ArnoldG K Radda
May 28, 1981·The New England Journal of Medicine·B D RossJ Falconer-Smith
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B ChanceA Sapega
Mar 29, 1954·The Journal of Physiology·P A MERTON

Citations

Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·H TakahashiY Itai
Aug 1, 1993·Cardiovascular Drugs and Therapy·N S Cook, I D Chapman
Apr 26, 1996·Neuroscience Letters·U IssbernerK H Steen
Nov 13, 2004·Annales de réadaptation et de médecine physique : revue scientifique de la Société française de rééducation fonctionnelle de réadaptation et de médecine physique·B DemontyA-Y Pasquier
Nov 21, 2007·Topics in Magnetic Resonance Imaging : TMRI·Christopher M Kramer
Feb 1, 1990·British Journal of Clinical Pharmacology·W H Aellig
Dec 5, 2015·Frontiers in Physiology·Terence E RyanJoseph M McClung
Sep 29, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Eric A MellonJerry D Glickson
Dec 1, 1990·European Journal of Vascular Surgery·L J HandsG K Radda
Jun 6, 2006·Journal of the American College of Cardiology·David C IsbellChristopher M Kramer
Jun 16, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·B L PedersenB Quistorff
Jun 1, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Oleksandr KhegaiProdromos Parasoglou
Oct 2, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Prodromos ParasoglouRavinder R Regatte
Jan 1, 1988·Medicinal Research Reviews·N E MacKenzie, P R Gooley
Aug 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H D SostmanD Moore
Dec 1, 1988·Clinical Physiology·O HenriksenC Thomsen
Oct 3, 2003·Medicine and Science in Sports and Exercise·Aya KitaharaToshihito Katsumura
Mar 30, 2017·Frontiers in Physiology·Victoria G RontoyanniCraig Porter
Aug 13, 1999·Journal of Applied Physiology·T BinzoniP Cerretelli

Related Concepts

Arterial Occlusive Diseases
Energy Metabolism
Intracellular Fluid
Leg
Muscle
In Vivo NMR Spectroscopy
Neoton
Red Phosphorus
Regional Blood Flow

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