Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus

Frontiers in Molecular Neuroscience
Susan McQuownMarco Peters

Abstract

Augmentation of cyclic nucleotide signaling through inhibition of phosphodiesterase (PDE) activity has long been understood to enhance memory. Efforts in this domain have focused predominantly on PDE4, a cAMP-specific phosphodiesterase implicated in consolidation. But less is known about the function of other PDEs expressed in neuroanatomical regions critical to memory. The PDE1 isoforms are the only PDEs to regulate neuronal cAMP and cGMP levels in a Ca2+/Calmodulin (CaM) dependent manner. Here, we show that knock-down of PDE1B in hippocampus of adult mice enhances contextual and spatial memory without effect on non-cognitive behaviors. Pharmacological augmentation of memory in rats was observed with a selective inhibitor of PDE1 dosed before and immediately after training, but not with drug dosed either 1 h after training or before recall. Our data clearly demonstrate a role for the PDE1B isoforms as negative regulators of memory, and they implicate PDE1 in an early phase of consolidation, but not retrieval. Inhibition of PDE1B is a promising therapeutic mechanism for treating memory impairment.

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Citations

Mar 14, 2020·Brain Circulation·Hayder M Al-KuraishyFarah Al-Mamorry
Dec 6, 2020·Neurobiology of Learning and Memory·Susan McQuownMarco Peters
Jan 9, 2021·Molecular Psychiatry·Sébastien Delhaye, Barbara Bardoni
Aug 28, 2021·Neuron·Nathaniel C NoyesRonald L Davis

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