Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serum.

Infection and Immunity
Lisa A LewisW M Shafer

Abstract

The capacity of Neisseria gonorrhoeae to cause disseminated gonococcal infection requires that such strains resist the bactericidal action of normal human serum. The bactericidal action of normal human serum against N. gonorrhoeae is mediated by the classical complement pathway through an antibody-dependent mechanism. The mechanism(s) by which certain strains of gonococci resist normal human serum is not fully understood, but alterations in lipooligosaccharide structure can affect such resistance. During an investigation of the biological significance of phosphoethanolamine extensions from lipooligosaccharide, we found that phosphoethanolamine substitutions from the heptose II group of the lipooligosaccharide beta-chain did not impact levels of gonococcal (strain FA19) resistance to normal human serum or polymyxin B. However, loss of phosphoethanolamine substitution from the lipid A component of lipooligosaccharide, due to insertional inactivation of lptA, resulted in increased gonococcal susceptibility to polymyxin B, as reported previously for Neisseria meningitidis. In contrast to previous reports with N. meningitidis, loss of phosphoethanolamine attached to lipid A rendered strain FA19 susceptible to complement killing. Ser...Continue Reading

References

Nov 1, 1990·The Journal of Clinical Investigation·J K Spitznagel
Apr 1, 1989·Clinical Microbiology Reviews·P A Rice
Feb 1, 1984·The Journal of Infectious Diseases·W M ShaferP F Sparling
May 1, 1981·Infection and Immunity·J G CannonP F Sparling
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·A BanerjeeD C Stein
Jan 15, 1999·Critical Reviews in Microbiology·C M Kahler, D S Stephens
Jul 21, 2005·Journal of Bacteriology·Yih-Ling TzengDavid S Stephens
Nov 7, 2007·Infection and Immunity·Lisa A LewisPeter A Rice

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Citations

Feb 1, 2012·Nature Reviews. Microbiology·Alison K Criss, H Steven Seifert
Oct 12, 2010·Clinical Microbiology Reviews·Sanjay RamPeter A Rice
Oct 23, 2012·Journal of Bacteriology·William T DoerrlerLisa A Boughner
May 1, 2015·Antibiotics·Victor I Band, David S Weiss
Feb 25, 2014·Clinics in Dermatology·Henry J C de Vries
Feb 24, 2015·Biochimica Et Biophysica Acta·Margaret E Bauer, William M Shafer
Nov 12, 2015·Biochimica Et Biophysica Acta·Daniela XhindoliAlessandro Tossi
Dec 30, 2014·Cellular Microbiology·Jonathan W Handing, Alison K Criss
Jul 18, 2012·Critical Reviews in Microbiology·José Luis Anaya-LópezAlejandra Ochoa-Zarzosa
Feb 22, 2012·FEMS Microbiology Letters·Samantha Gruenheid, Hervé Le Moual
Nov 30, 2013·Pharmaceuticals·Ali Adem Bahar, Dacheng Ren
Apr 9, 2014·Infection and Immunity·Michael A Apicella
May 14, 2014·Antimicrobial Agents and Chemotherapy·Justin L KandlerWilliam M Shafer
Aug 22, 2014·Clinical and Vaccine Immunology : CVI·Jutamas ShaughnessySanjay Ram
Apr 21, 2019·Antibiotics·Rajesh KuppusamyNaresh Kumar
Oct 23, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Milad AbdiNour Amirmozafari
Sep 22, 2017·PLoS Pathogens·Stephanie A Ragland, Alison K Criss
Mar 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sunita GulatiSanjay Ram
Sep 10, 2017·Annual Review of Microbiology·Peter A RiceAnn E Jerse

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