PMID: 9434897Jan 22, 1998Paper

Phosphohistidines in bacterial signaling

Current Opinion in Structural Biology
M M McEvoy, F W Dahlquist

Abstract

The movement of Gram-negative bacteria in response to nutrients in the environment is driven by two interlinked chemotaxis systems, the methyl-accepting chemotaxis protein (MCP)-mediated pathway, and the phosphoenolpyruvate: sugar phosphotransferase (PTS)-mediated pathway. The physical link connecting the two systems is unclear, but the common utilization of histidine-containing phosphocarrier proteins is an intriguing similarity. The recent structure determinations of several proteins from the PTS-mediated pathway, the phosphotransfer domain from the kinase CheA of the MCP-mediated chemotaxis pathway, and a homologous kinase, ArcB, enable the comparison of the histidine active sites of these systems. Overall, the tertiary folds of the proteins are quite different, as are the structural details of the histidine active sites within the proteins, and therefore there is not an obvious structural homolog via which the two pathways communicate, despite their similar chemical mechanisms.

References

Jan 1, 1992·Annual Review of Genetics·J S Parkinson, E C Kofoid
Mar 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·O HerzbergG Kapadia
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D WorthylakeS J Remington
Jul 7, 1995·Journal of Molecular Biology·A H WestA M Stock
Dec 1, 1994·Current Opinion in Structural Biology·O Herzberg, R Klevit
May 1, 1994·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Z JiaE B Waygood
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·M FeeseS J Remington
Sep 1, 1993·Microbiological Reviews·P W PostmaG R Jacobson
Jan 1, 1993·Journal of Cellular Biochemistry·F Titgemeyer
Jan 1, 1995·Annual Review of Microbiology·D F Blair
Dec 1, 1995·Protein Science : a Publication of the Protein Society·K PullenR E Klevit
Mar 1, 1996·Protein Science : a Publication of the Protein Society·N A Van NulandG T Robillard

❮ Previous
Next ❯

Citations

Apr 5, 2002·Chembiochem : a European Journal of Chemical Biology·Yulei WangDavid G Lynn
Dec 26, 2001·Current Opinion in Structural Biology·H van Tilbeurgh, N Declerck
Jun 9, 1999·Bioorganic & Medicinal Chemistry Letters·C SchenkelsJ L Reymond
Jun 22, 1999·Chemistry & Biology·M C Pirrung
Feb 25, 2011·Molecular BioSystems·Julie PerryGerard Wright
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·S S Mahmoud, R B Croteau
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Soheil S Mahmoud, Rodney B Croteau
Dec 5, 2009·The Journal of Biological Chemistry·Katsumasa IrieYoshinori Fujiyoshi
Apr 22, 2009·Annual Review of Microbiology·John R Kirby
Dec 8, 2004·Advances in Enzyme Regulation·David A OkarAlex J Lange
Aug 31, 2000·Annual Review of Biochemistry·A M StockP N Goudreau
Jun 16, 1999·Structure·V L Robinson, A M Stock
Apr 21, 2017·Protein Science : a Publication of the Protein Society·Wenlin PanGerald L Hazelbauer
Jun 9, 2004·Journal of Computational Chemistry·Yuri A KosinskyRoman G Efremov
Mar 23, 2021·Critical Reviews in Microbiology·Lucindo Cardoso de PinaL Caetano M Antunes
Feb 12, 2002·Bioorganic & Medicinal Chemistry·Masayuki Matsushita, Kim D Janda
Dec 12, 2000·The Journal of Organic Chemistry·M C PirrungV S Rana

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.