Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation.

The Journal of Biological Chemistry
M Lopez-IlasacaR Wetzker

Abstract

Jun kinases (JNK) are involved in the stress response of mammalian cells. Stimulation of JNK can be induced by stress factors and by agonists of tyrosine kinase and G protein-coupled receptors. G protein-dependent receptors stimulate JNK via Gbetagamma subunits of heterotrimeric G proteins, but the subsequent signaling reaction has been undefined. Here we demonstrate JNK activation in COS-7 cells by Gbetagamma-stimulated phosphoinositide 3-kinase gamma (PI3Kgamma). Signal transduction from PI3Kgamma to JNK can be suppressed by dominant negative mutants of Ras, Rac, and the protein kinase PAK. These results identify PI3Kgamma as a mediator of Gbetagamma-dependent regulation of JNK activity.

References

Nov 24, 1995·The Journal of Biological Chemistry·S BagrodiaR A Cerione
Mar 1, 1995·Trends in Biochemical Sciences·E Cano, L C Mahadevan
May 12, 1994·Nature·J M KyriakisJ R Woodgett
Oct 1, 1996·Current Biology : CB·A J Ridley
Mar 17, 1997·Biochemical and Biophysical Research Communications·M Lopez-IlasacaM A Heidaran

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Citations

Mar 31, 2005·Archives of Biochemistry and Biophysics·Alejandra S GubermanEduardo T Cánepa
Oct 3, 2003·Biochemical and Biophysical Research Communications·Melissa A Fleegal, Colin Sumners
Jan 27, 2004·Brain Research. Molecular Brain Research·Vardit RubovitchYosef Sarne
Jun 22, 1999·European Journal of Pharmacology·N ParameswaranW S Spielman
Jun 4, 1999·European Journal of Pharmacology·N ParameswaranP Nambi
May 22, 2002·Cellular Signalling·Eugenio JiménezMercedes Montiel
Nov 21, 2000·The International Journal of Biochemistry & Cell Biology·A A Maghazachi
May 3, 2012·Journal of Medicinal Chemistry·James W LeahyOlivia Raeber
Nov 3, 2006·Nature Reviews. Drug Discovery·Thomas RückleChristian Rommel
Oct 27, 2001·Acta Physiologica Scandinavica·A RapacciuoloH A Rockman
Mar 2, 2002·Immunology·Adam P CurnockStephen G Ward
Apr 20, 2004·Assay and Drug Development Technologies·Deirdre K Luttrell, Louis M Luttrell
Jun 3, 2004·British Journal of Pharmacology·Anthony S L Chan, Yung H Wong
Dec 8, 2004·Advances in Enzyme Regulation·Regina PietruchaReinhard Wetzker
Dec 6, 2005·Plant Physiology and Biochemistry : PPB·Chung-Wen LinHao-Jen Huang
Feb 1, 2003·Journal of Neurochemistry·Angel Y F KamYung H Wong
Dec 2, 1999·Experimental Cell Research·L Kjoller, A Hall
Sep 5, 2019·Biomolecules·Bernd Nürnberg, Sandra Beer-Hammer
Sep 25, 1998·The Journal of Biological Chemistry·Y OkuboD Le Roith

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