Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases

Advances in Biological Regulation
Suyong ChoiRichard A Anderson

Abstract

Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger phosphatidylinositol 4,5-bisphosphate (PI4,5P2) that controls essentially all aspects of cellular functions. PI4,5P2 rapidly diffuses in the membrane of the lipid bilayer and does not greatly change in membrane or cellular content, and thus PI4,5P2 generation by PIPKs is tightly linked to its usage in subcellular compartments. Based on this verity, recent study of PI4,5P2 signal transduction has been focused on investigations of individual PIPKs and their underlying molecular regulation of cellular processes. Here, we will discuss recent advances in the study of how PIPKs control specific cellular events through assembly and regulation of PI4,5P2 effectors that mediate specific cellular processes. A focus will be on the roles of PIPKs in control of the phosphoinositide 3-kinase pathway and autophagy.

References

Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·D MassenburgM Vaughan
Dec 13, 2001·Developmental Cell·R H Insall, O D Weiner
May 4, 2002·Annual Review of Biophysics and Biomolecular Structure·Stuart McLaughlinDiana Murray
Aug 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Valerie CarricaburuLucia E Rameh
May 15, 2004·Molecular and Cellular Biology·Katja A LamiaLewis C Cantley
Aug 25, 2004·The International Journal of Biochemistry & Cell Biology·Isei TanidaEiki Kominami
Oct 13, 2006·Nature·Gilbert Di Paolo, Pietro De Camilli
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Gerrit van MeerGerald W Feigenson
Feb 8, 2008·Molecular Biology of the Cell·Urszula GolebiewskaStuart McLaughlin
Sep 5, 2008·Annual Review of Pathology·Nader Chalhoub, Suzanne J Baker
Feb 7, 2009·Physiology·Heather J McCrea, Pietro De Camilli
Mar 12, 2009·Experimental Cell Research·Alexander Sorkin, Lai Kuan Goh
Jun 6, 2009·Nature Reviews. Molecular Cell Biology·Hitoshi NakatogawaYoshinori Ohsumi
Oct 23, 2009·Trends in Cell Biology·Christy A BarlowRichard A Anderson
Nov 6, 2009·Journal of Cell Science·Iman van den Bout, Nullin Divecha
Nov 10, 2009·Advances in Enzyme Regulation·Yuji FunakoshiYasunori Kanaho
Apr 10, 2010·Nature Reviews. Molecular Cell Biology·Bart VanhaesebroeckBenoit Bilanges
Sep 3, 2010·Nature Cell Biology·Zhifen Yang, Daniel J Klionsky
Oct 15, 2010·Journal of Cellular Physiology·Yuji FunakoshiYasunori Kanaho
Jan 25, 2011·Nature Cell Biology·Joungmok KimKun-Liang Guan
May 10, 2011·Science·Matthew C GoodWendell A Lim
Jul 16, 2011·Biochemical and Biophysical Research Communications·Yang XiaMaria-Luisa Giudici
Feb 22, 2012·The Journal of Cell Biology·Kevin MoreauDavid C Rubinsztein
Mar 23, 2012·Biochemical Society Transactions·Emily R EdenClare E Futter
Dec 12, 2012·The Journal of Cell Biology·Fubito NakatsuPietro De Camilli
Jan 12, 2013·Current Biology : CB·Claudia Dall'ArmiGilbert Di Paolo
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Amit GuptaPadinjat Raghu
Aug 1, 2013·Physiological Reviews·Tamas Balla
Dec 4, 2013·Trends in Cell Biology·Alejandra TomasEmily R Eden
Feb 4, 2014·Current Biology : CB·Louise FetsRobert R Kay
Jul 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Julius SemenasJenny L Persson
Jan 13, 2015·Molecular Cell·Mariella VicinanzaDavid C Rubinsztein

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Citations

Mar 20, 2019·Nature Cell Biology·Suyong ChoiRichard A Anderson
Dec 20, 2019·ACS Chemical Biology·Fabian HertelJin Zhang

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