PMID: 18407216Aug 1, 1994Paper

Phosphoinositides and calcium signaling New aspects and diverse functions in cell regulation

Trends in Endocrinology and Metabolism : TEM
T Balla, K J Catt

Abstract

Numerous circulating and locally produced hormones bind to specific cell-surface receptors and activate a variety of second-messenger pathways that evoke characteristic phenotypic responses in their target cells. One of the most ubiquitous signal transduction mechanisms is the phosphoinositide-calcium messenger system, which is activated by hormones, neurotransmitters, and growth factors. Stimulation of these receptors by their ligands causes a characteristic change in the metabolism of membrane phospholipids with production of diacylglycerol and a rapid increase in cytoplasmic Ca(2+) concentration, due to the release of stored intracellular Ca(2+) and stimulated Ca(2+) entry from the extracellular space. These intracettular signals act in concert to activate protein kinases that phosphorylate a variety of regulatory proteins. The link between phosphoinositide turnover and Ca(2+) mobilization is inositol 1,4,5-trisphosphate, the major Ca(2+)-mobilizing second messenger, which is produced from membrane phosphoinositides by activated phospholipase C enzymes. The mechanisms of ligand-regulated Ca(2+) influx and the additional regulatory role(s) of phosphoinositides and inositol phosphates are still being unfolded. This review and ...Continue Reading

References

Mar 25, 1975·Biochimica Et Biophysica Acta·R H Michell
Aug 31, 1992·Biochemical and Biophysical Research Communications·S M VoglmaierA B Theibert
Nov 2, 1990·Cell·P W MajerusV S Bansal
Sep 15, 1988·Biochemical and Biophysical Research Communications·J ZwillerA L Boynton
Dec 30, 1988·Biochemical and Biophysical Research Communications·L HunyadyK J Catt
Jan 1, 1988·The Biochemical Journal·L StephensP C Downes
Feb 1, 1993·Trends in Biochemical Sciences·F S MennitiS B Shears
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A D ShortD L Gill
Aug 13, 1993·Cell·N DivechaR F Irvine
Aug 1, 1994·Trends in Endocrinology and Metabolism : TEM·J W Putney, G S Bird

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Citations

Aug 26, 1998·Molecular Reproduction and Development·M N Llanos
Apr 1, 1997·Cell Biology International·W Zhang, G M Roomans
Dec 1, 2004·Basic & Clinical Pharmacology & Toxicology·Dagny SandnesJan-Bjørn Osnes
Aug 1, 1994·Trends in Endocrinology and Metabolism : TEM·J W Putney, G S Bird
Jul 14, 1995·The Journal of Biological Chemistry·B Somasundaram, M P Mahaut-Smith

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