Phosphoinositides and calcium signaling New aspects and diverse functions in cell regulation
Abstract
Numerous circulating and locally produced hormones bind to specific cell-surface receptors and activate a variety of second-messenger pathways that evoke characteristic phenotypic responses in their target cells. One of the most ubiquitous signal transduction mechanisms is the phosphoinositide-calcium messenger system, which is activated by hormones, neurotransmitters, and growth factors. Stimulation of these receptors by their ligands causes a characteristic change in the metabolism of membrane phospholipids with production of diacylglycerol and a rapid increase in cytoplasmic Ca(2+) concentration, due to the release of stored intracellular Ca(2+) and stimulated Ca(2+) entry from the extracellular space. These intracettular signals act in concert to activate protein kinases that phosphorylate a variety of regulatory proteins. The link between phosphoinositide turnover and Ca(2+) mobilization is inositol 1,4,5-trisphosphate, the major Ca(2+)-mobilizing second messenger, which is produced from membrane phosphoinositides by activated phospholipase C enzymes. The mechanisms of ligand-regulated Ca(2+) influx and the additional regulatory role(s) of phosphoinositides and inositol phosphates are still being unfolded. This review and ...Continue Reading
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