PMID: 6966111Jan 1, 1980Paper

Phospholipase B activity in congenitally athymic (nude) mice infected with Trichinella spiralis

Zeitschrift Für Parasitenkunde
A J Groven, G W Moore

Abstract

The effects of an infection with 200 Trichinella spiralis larvae on the intestinal phospholipase B activity and bone marrow eosinophilia of congenitally athymic (nude) mice (BALB/c; NU/NU) were studied. Nude mice were used since it had been shown that they do not undergo a typical worm expulsion and also they lack a thymus. The results showed that nude mice do not develop either an increased bone marrow eosinophilia or an elevation in intestinal phospholipase B activity. The findings thus support the hypothesis that phospholipase B is involved in the expulsion of parasitic worms and that elevated enzyme levels and expulsion are thymus cell dependent.

Citations

Oct 1, 1984·International Journal for Parasitology·S D Wilkes, A J Goven
Apr 1, 1989·International Journal for Parasitology·T L Rothwell
Oct 1, 1989·Biochemical Medicine and Metabolic Biology·H E Laubach

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